Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis

Table 5 Predictors of outcomes of the 102 patients with cryptogenic cirrhosis

Outcome	Univariate analysis, OR (95%CI)	P value	Multivariate analysis, OR (95%CI)	P value
Liver decompensation
Age at diagnosis	1.06 (1.01-1.11)	< 0.01	0.97 (0.90-1.05)	NS
Male sex	1.00 (0.41-2.40)	NS	0.85 (0.18-4.12)	NS
Child B vs A	40.0 (8.03-199)	< 0.001	111 (11-1101)	< 0.001
Child C vs A	60.8 (7.2-513)	< 0.001	102 (7-1480)	< 0.001
Renal impairment1	3.75 (1.14-12.3)	< 0.023	2.90 (0.40-21.1)	NS
Hyponatremia2	4.45 (1.50-13.2)	< 0.005	2.89 (0.48-17.4)	NS
Hepatocellular carcinoma
Age at diagnosis	1.04 (0.99-1.10)	NS	1.03 (0.95-1.12)	NS
Male sex	2.30 (0.79-6.70)	NS	2.38 (0.67-8.44)	NS
Child B vs A	1.09 (0.31-3.84)	NS	0.62 (0.13-2.86)	NS
Child C vs A	1.67 (0.46-6.10)	NS	0.76 (0.14-4.04)	NS
Renal impairment1	3.62 (1.18-11.0)	< 0.019	2.37 (0.52-10.9)	NS
Hyponatremia2	4.37 (1.18-13.15)	< 0.006	4.11 (1.14-14.9)	< 0.031

¹Renal impairment: serum creatinine > 1.20 mg/dL;

²Hyponatremia: serum Na < 135 mE/L. In addition to the variables reported in the table, analysis included also: ALT/AST, α-fetoprotein, metabolic syndrome, obesity, serum cholesterol, type 2 diabetes mellitus, cardiovascular events. NS: Not significant.