Prognostic significance of preoperative and postoperative CK19 and CEA mRNA levels in peripheral blood of patients with gastric cardia cancer

Table 3 Univariate and multivariate analyses of the clinicopathological variables for overall survival in 129 patients with gastric cardia cancer

Clinicopathological feature	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Gender	1.377 (0.797-2.377)	0.245
Age (yr)	0.812 (0.529-1.247)	0.336
Tumor size(cm)	1.688 (1.097-2.596)	0.015	1.305 (0.816-2.089)	0.267
Histological grade	1.277 (1.008-1.619)	0.039	1.104 (0.860-1.418)	0.436
Depth of tumor invasion	1.985 (1.162-3.393)	0.010	1.191 (0.660-2.151)	0.562
Lymph node status	2.894 (1.864-4.492)	0.000	1.848 (1.109-3.079)	0.018
Pre-CK19 mRNA	1.932 (1.247-2.992)	0.002	1.625 (1.035-2.553)	0.035
Post-CK19 mRNA	1.431 (0.932-2.197)	0.096
Pre-CEA mRNA	2.337 (1.443-3.784)	0.000	1.918 (1.162-3.166)	0.011
Post-CEA mRNA	1.609 (1.039-2.492)	0.030	1.213 (0.753-1.955)	0.427

CK19: Cytokeratin 19; CEA: Carcinoembryonic antigen; HR: Hazard ratio.