Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?

Table 6 Statistical correlations between Tumor Node Metastasis stage variation and clinico-pathological variables

	pTNM stage variation			P value
Variable	None	Downstaging	Upstaging
Sex
M	53	81	7
F	27	41	6	0.655
Age
≤ 67 yr	36	65	5
> 67 yr	44	57	8	0.372
Site
Upper	26	60	7
Medium	11	18	3
Lower	35	41	1
Extensive	8	3	2	0.0194
Circumferential spread
One-third	31	55	8
Middle	25	36	1
Complete	24	31	4	0.396
Craniocaudal extension
< 3 cm	17	29	5
≥ 3 cm	63	93	8	0.4
Distance from the anal verge
≥ 1 cm	3	7	1
< 1 cm	77	115	12	0.747
Histotype
NOS	70	117	13
Mucinous	10	5	0	0.043
Histological grade
1	4	2	0
2	60	108	11
3	16	12	2	0.135
cT
2	4	8	0
3	58	100	12
4	18	14	1	0.185
cN
cN0	27	58	13
cN+	53	64	0	< 0.0001
Dworak grade
0	20	11	3
1	35	33	8
2	22	26	3
3	2	19	0
4	1	33	0	< 0.0001
Death due to disease
No	47	101	9
Yes	33	11	4	< 0.0001
Recurrence
No	42	91	9
Yes	38	31	4	0.0051