Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?

Table 1 Clinico-pathological features of 215 rectal carcinomas treated with neo-adjuvant chemo-radiotherapy n (%)

Variables	Category	n	Death due to disease	Recurrence
Sex	M	141	35 (25)	43 (30)
	F	74	23 (31)	30 (40)
Age	≤ 67 yr	106	24 (23)	32 (30)
	> 67 yr	109	34 (31)	41 (38)
Site	Upper	93	23 (25)	30 (32)
	Medium	32	10 (31)	13 (41)
	Lower	77	21 (27)	26 (34)
	Extensive	13	4 (31)	4 (31)
Circumferential spread	One-third	94	24 (26)	32 (34)
	One middle	62	17 (27)	21 (34)
	Complete	59	17 (29)	20 (34)
Craniocaudal extension	< 3 cm	51	7 (14)	10 (20)
	≥ 3 cm	164	51 (31)	63 (38)
Distance from the anal verge	≥ 1 cm	204	56 (27)	2 (18)
	< 1 cm	11	2 (18)	71 (35)
Histological grade	1	6	0 (0)	0 (0)
	2	179	47 (26)	61 (34)
	3	30	11 (37)	12 (40)
Histotype	NOS	200	53 (26)	67 (33)
	Mucinous	15	5 (33)	6 (40)
cT	cT2	12	1 (8)	2 (17)
	cT3	170	43 (25)	54 (32)
	cT4	33	14 (42)	17 (51)
cN	cN0	98	21 (21)	28 (28)
	cN+	117	37 (32)	45 (38)
yT	yT0	35	3 (9)	8 (23)
	yT1	19	1 (5)	1 (5)
	yT2	61	13 (21)	16 (26)
	yT3	83	32 (39)	36 (43)
	yT4	17	9 (53)	12 (70)
yN	yN0	146	28 (91)	38 (26)
	yN+	69	30 (43)	35 (51)
yM	yM0	212	56 (20)	70 (33)
	yM+	3	2 (67)	3 (100)
y stage	T0N0M0	33	3 (9)	8 (24)
	1	63	10 (16)	13 (21)
	2	50	15 (30)	17 (34)
	3	66	28 (42)	32 (48)
	4	3	2 (67)	3 (100)
TNM Stage variation	None	80	33 (41)	38 (47)
	Downstaging	119	19 (16)	28 (23)
	Upstaging	16	6 (38)	7 (44)
T stage variation	None	86	34 (40)	41 (48)
	Downstaging	122	22 (18)	29 (24)
	Upstaging	7	2 (29)	3 (43)
N stage variation	None	141	43 (31)	55 (39)
	Downstaging	61	11 (18)	14 (23)
	Upstaging	13	4 (31)	4 (31)
Dworak Regression grade	0	34	16 (47)	19 (56)
	1	76	20 (26)	26 (24)
	2	50	16 (32)	16 (32)
	3	21	3 (14)	4 (19)
	4	34	3 (9)	8 (23)
Regression	Absent/partial	160	52 (33)	61 (38)
	Total/subtotal	55	6 (11)	12 (22)
Radial margin	Negative	201	51 (25)	65 (32)
	Positive	14	7 (50)	8 (57)
Adjuvant chemotherapy	No	47	16 (34)	18 (38)
	Yes	80	24 (30)	31 (39)