Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma

Table 2 Univariate analyses for disease-free survival, overall survival and disease-specific survival after hepatic resection

	DFS		OS		DSS
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Age ( ≤ 70 yr)	0.777 (0.434-1.389)	0.3948	0.959 (0.529-1.739)	0.8915	0.757 (0.360-1.591)	0.4622
Gender (male)	0.742 (0.382-1.443)	0.3796	1.466 (0.653-3.291)	0.3537	1.351 (0.515-3.545)	0.5404
Occult HBV infection	1.052 (0.564-1.961)	0.8736	1.184 (0.628-2.232)	0.6009	1.328 (0.625-2.821)	0.4604
Alcohol abuse	0.700 (0.326-1.503)	0.3605	1.492 (0.749-2.969)	0.2549	1.489 (0.631-3.514)	0.3639
Smoking (Ex vs current)	0.405 (0.182-0.903)	0.0271	0.451 (0.215-0.945)	0.0349	0.299 (0.113-0.795)	0.0155
Smoking (Ex vs never)	0.680 (0.319-1.453)	0.3197	1.295 (0.597-2.807)	0.5132	0.905 (0.328-2.501)	0.848
Smoking (current vs never)	1.680 (0.874-3.230)	0.1199	2.869 (1.417-5.807)	0.0034	3.026 (1.315-6.968)	0.0092
Smoking (Ex + current vs never)	1.078 (0.606-1.920)	0.7976	1.926 (1.019-3.640)	0.0436	1.735 (0.804-3.745)	0.1604
Smoking (current vs other)	1.926 (1.047-3.544)	0.035	2.569 (1.397-4.724)	0.0024	3.144 (1.497-6.604)	0.0025
Diabetes mellitus	0.894 (0.474-1.685)	0.7285	1.715 (0.941-3.126)	0.0779	1.414 (0.665-3.008)	0.3681
Pathological NASH	1.222 (0.516-2.892)	0.649	1.076 (0.423-2.736)	0.8781	1.342 (0.465-3.873)	0.5863
Obesity	0.989 (0.535-1.828)	0.9714	1.049 (0.556-1.981)	0.8827	1.183 (0.549-2.549)	0.6673
Fibrosis	1.163 (0.699-1.936)	0.5608	1.004 (0.583-1.729)	0.9883	1.407 (0.742-2.670)	0.2956
Vp	2.428 (1.338-4.407)	0.0035	1.892 (1.042-3.436)	0.0362	1.918 (0.919-4.002)	0.0828
T factor (T3/4 vs T1/2)	3.220 (1.680-6.169)	0.0004	1.793 (0.984-3.268)	0.0565	2.222 (1.052-4.693)	0.0364
Multiple tumors	3.275 (1.784-6.014)	0.0001	2.009 (1.110-3.636)	0.0211	2.767 (1.329-5.761)	0.0065

Vp: Portal vein invasion; DFS: Disease-free survival; DSS: Disease-specific survival; HBV: Hepatitis B virus; NASH: Non-alcoholic steatohepatitis; OS: Overall survival.