Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity

Table 4 Univariate and multivariate analyses of cancer specific survival and disease free survival

	Univariate analysis CSS1		Multivariate analysis CSS12		Univariate analysis DFS3		Multivariate analysis DFS23
	5-yr CSS	P value	Hazard ratio	P value	5-yr DFS	P value	Hazard ratio	P value
Age (yr)	63%	0.009	1.7 (0.8-3.6)	0.155	71%	0.226	1.2 (0.5-2.9)	0.668
≥ 80	78%				79%
< 80
Gender		0.274	0.9 (0.5-1.6)	0.762		0.682	1.1 (0.5-2.2)	0.865
Male	68%				77%
Female	73%				74%
Ethnicity		0.293	-	-		0.608	-	-
Ashkenazi	73%				73%
Sephardic	65%				78%
Arab	88%				69%
Other	79%				93%
Second malignancies		0.497	-	-		0.429	-	-
Yes	75%				81%
No	70%				74%
Family hx of cancer		0.068	-	-		0.096	-	-
Yes	78%				82%
No	68%				71%
Family hx of CRC		0.024	0.3 (0.1-0.8)	0.015		0.048	0. 2 (0.1-0.8)	0.016
Yes	86%				91%
No	70%				73%
Performance status		0.0003	1.2 (0.5-3)	0.62		0.068	2.1 (0.7-6.3)	0.175
0-1	77%				78%
2-4	53%				60%
Mode of Diagnosis		0.024	1 (0.3-3.4)	0.973		0.235	-	-
Symptoms	68%				74%
Screening	90%				85%
Tumor location		0.102	-	-		0.723	-	-
Right colon	66%				77%
Left colon/rectum	75%				75%
Histology		< 0.0001	5.7 (1.5-21.1)	0.009		< 0.0001	6.9 (1.7-28)	0.007
NOS/mucinous/other	74%				77%
Signet ring cell	33%				48%
Grade		0.05	-	-		0.561	-	-
1	87%				71%
2-3	69%				76%
T			-	-			-	-
T1	92%	< 0.0001			100%	< 0.0001
T2	90%				82%
T3	73%				72%
T4	39%				76%
N		0.0003	-	-		0.001	-	-
N0	89%				81%
N1	79%				72%
N2	56%				57%
M		< 0.0001	-	-	-	-	-	-
M0	85%
M1	26%
TNM stage		< 0.0001		-		0.014
I	94%		1	0.433	90%		1	-
II	90%		1.9 (0.4-8.7)	0.013	77%		3.5 (0.8-15.6)	0.107
III	73%		6.7 (1.5-30.1)	< 0.0001	63%		8.4 (1.9-36.4)	0.004
IV	26%		20 (4.6-87.6)		-		-	-
LVI		0.073	-	-		0.848	-	-
Yes	57%				79%
No	75%				75%
VVI		0.272	-	-		0.791	-	-
Yes	65%				72%
No	75%				76%
Obstruction		0.001	2.3 (0.99-5.4)	0.052		0.001	2.95 (1.1-7.9)	0.03
Yes	49%				49%
No	74%				79%
Perforation		0.0001	3.5 (1.1-10.9)	0.028		0.262	-	-
Yes	28%				64%
No	73%				76%
Adjuvant/neoadjuvant tx			-	-			-	-
Yes	87%	0.137			72%	0.236
No	78%				80%
Local Tx to metastatic sites			-	-	-	-	-	-
Yes	41%	0.007
No	20%

¹Univariate and multivariate analysis for CSS were performed for patients with stage I-IV;

²Multivariate analysis was calculated for the entire follow-up period. The column of multivariate analysis depicts only factors that were included in the model;

³Univariate and multivariate analysis for DFS were performed for patients with stage I-III. DFS: Disease free survival; CRC: Colorectal cancer; CSS: Cancer specific survival; LVI: Lymphovascular invasion; NA: Not applicable; NOS: Not otherwise specified; Tx: Treatment; VVI: Venovascular invasion.