Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity

doi:10.3748/wjg.v23.i8.1387

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Feb 28, 2017; 23(8): 1387-1396
Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1387

Table 2 Tumor characteristics¹n (%)

	Study cohort	Older (age ≥ 80 yr)	Younger (age < 80 yr)	P value
	(n = 350)	(n = 175)	(n = 175)	P value
Tumor location²
Right colon	140 (40)	80 (45.7)	60 (34.3)	0.029
Left colon/rectum	210 (60)	95 (54.3)	115 (65.7)
Histology				0.201
NOS	260 (76.5)	124 (74.2)	136 (78.6)
Mucinous	64 (18.8)	38 (22.8)	26 (15)
Signet ring cell	11 (3.2)	3 (1.8)	8 (4.6)
Other	5 (1.5)	2 (1.2)	3 (1.78)
Grade³				0.025
1	48 (14.8)	17 (10.4)	31 (19.3)
2-3	276 (85.2)	146 (89.3)	130 (80.7)
T				0.27
T1	17 (5.2)	5 (3.1)	12 (7.4)
T2	57 (17.6)	28 (17.4)	29 (17.8)
T3	237 (73.2)	123 (76.4)	114 (69.9)
T4	13 (4)	5 (3.1)	8 (4.9)
N				0.357
N0	179 (67)	94 (71.2)	85 (63)
N1	56 (21)	24 (18.2)	32 (23.7)
N2	32 (12)	14 (10.6)	18 (13.3)
M1	72 (20.7)	34 (19.8)	38 (21.7)	0.655
TNM stage				0.259
I	65 (19)	30 (17.7)	35 (20.2)
II	116 (33.8)	66 (38.8)	50 (28.9)
III	90 (26.2)	40 (23.5)	50 (28.9 )
IV	72 (21)	34 (20)	38 (22)
LVI	18 (6)	11 (7.5)	7 (4.6)	0.296
VVI	36 (11.9)	15 (10.1)	21 (13.6)	0.348
Obstruction⁴	36 (10.3)	22 (12.6)	14 (8)	0.159
Perforation⁴	12 (3.4)	10 (5.7)	2 (1.1)	0.019
Synchronous CRC	11 (3.1)	4 (2.3)	7 (4)	0.358
Metachronous CRC	2 (0.6)	1 (0.6)	1 (0.6)	0.997
RAS mutated	8 (22.2)	2 (15.4)	6 (26.1)	0.458
BRAF mutated	1 (3.7)	0 (0)	1 (7.7)	0.29
MSI-H	6 (25)	3 (100)	3 (14.3)	0.001

¹Valid percentages. Missing data as follows: histology (n = 10); grade (n = 26); T stage (n = 26); N status (n = 83); M status (n = 3); TNM stage (n = 7); lymphatic invasion (n = 51); vascular invasion (n = 48); metachronous tumor (n = 1); KRAS (n = 314); BRAF (n = 323); MSI-H (n = 326);

²Right colon = appendix, ascending colon and transverse colon, Left colon = descending colon and sigma;

³Grade 1 = well differentiated, grade 2 moderately differentiated, poorly differentiated;

⁴Obstruction or perforation at presentation. CRC: Colorectal cancer; NOS: Not otherwise specified; LVI: Lymphovascular invasion; VVI: Venovascular invasion; MSI-H: Microsatellite instability- high.

Citation: Goldvaser H, Katz Shroitman N, Ben-Aharon I, Purim O, Kundel Y, Shepshelovich D, Shochat T, Sulkes A, Brenner B. Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity. World J Gastroenterol 2017; 23(8): 1387-1396
URL: https://www.wjgnet.com/1007-9327/full/v23/i8/1387.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i8.1387