Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity

Table 1 Patient characteristics¹n (%)

	Study cohort	Older (age ≥ 80 yr)	Younger (age < 80 yr)	P value
	(n = 350)	(n = 175)	(n = 175)
Median age (range)	80 (20-99)	83 (80-99)	63 (20-79)	-
Male gender	155 (44.3)	84 (48)	71 (40.6)	0.162
Ethnicity
Ashkenazi	193 (56.4)	112 (64.8)	81 (47.9)	< 0.001
Sephardic	120 (35.1)	58 (33.5)	62 (36.7)
Arab	12 (3.5)	0 (0)	12 (7.1)
Other	17 (5)	3 (1.7)	14 (8.3)
2nd malignancy	63 (18.1)	39 (22.4)	24 (13.7)	0.035
Family history of cancer	157 (51.1)	53 (36.3)	104 (64.6)	< 0.001
Family history of CRC	65 (21.2)	21 (14.4)	44 (27.3)	0.006
IBD	1 (0.3)	1 (0.6)	0 (0)	0.335
Polyps2	122 (35.4)	55 (33.2)	67 (38.5)	0.233
HNPCC/FAP	9 (2.7)	5 (3)	4 (2.4)	0.695
Smoking history	104 (34.9)	41 (24.6)	74 (44.3)	< 0.001
Diagnosis d/t screening	45 (12.9)	10 (5.7)	35 (20)	< 0.001
Performance status3 of 0-1	268 (82.5)	115 (71)	153 (93.9)	< 0.001

¹Valid percentages. Missing data as follows: ethnicity (n = 8); 2^nd malignancy (n = 1); family history of malignancy (n = 43); family history of CRC (n = 43); IBD (n = 5), polyps (n = 5); HNPCC/FAP (n = 14); smoking history (n = 16), performance status (n = 25);

²Polyps- diagnosis of polyps before or during CRC diagnosis;

³Performance status was determined according to the Eastern Cooperative Oncology Group score during the first encounter with the oncologist. CRC: Colorectal cancer; IBD: Inflammatory bowel disease; FAP: Familial adenomatous polyposis; HNPCC: Hereditary non-polyposis colorectal cancer; d/t: Due to.