Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model

Table 2 Effects of oral administration of Cd-EtOHE or Cd-HexP in chronic phase with relapse of intestinal inflammation in trinitrobenzenesulfonic acid-induced ulcerative colitis in rats

Group	Dose (mg/kg)	Lesion score	Weight/length (mg/cm)	Diarrhea (%)
Non-colitics	-		97 ± 9	0
Colitics	-	4.0 (3-6)	143 ± 14f	94
Cd-EtOHE	125	1.0 (1-4)a	132 ± 11f	56a
Cd-HexP	62.5	1.0 (1-4)b	122 ± 12be	56a

Results expressed as mean ± SD or median (minimum-maximum) of the parameters analyzed (n = 7-9). For the parametric data, mean ± SD was used, with ANOVA and a posteriori Dunnett’s test. For non-parametric data, median (minimum-maximum) was used, with Kruskal-Wallis test and a posteriori Dunn.

^aP < 0.05,

^bP < 0.01 vs colitic group;

^eP < 0.01 and

^fP < 0.001 vs non-colitic group. Cd: Combretum duarteanum; EtOHE: Ethanolic extract; HexP: Hexane phase.