Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model

Table 1 Effects of oral administration of Cd-EtOHE or Cd-HexP in acute phase of intestinal inflammation in trinitrobenzenesulfonic acid-induced ulcerative colitis in rats

Group	Dose (mg/kg)	ULA (mm2)	Inhibition (%)	Lesion score	Weight/length (mg/cm)	Diarrhea (%)
Non-colitics	-	-	100		110 ± 7.7	0
Colitics	-	107 ± 38	-	6.0 (5-7)	148 ± 17f	100
Cd-EtOHE	31.25	79 ± 31	26	5.0 (3-7)	152 ± 19f	100
	62.5	46 ± 12b	57	4.0 (1-5)a	146 ± 19f	57
	125	19 ± 8c	82	3.0 (2-5)b	134 ± 5d	14b
	250	76 ± 23	29	6.0 (4-7)	152 ± 14f	86
Non-colitics	-	-	-	-	102 ± 14	0
Colitics	-	101 ± 45	-	7.0 (5-8)	154 ± 27f	87
Cd-HexP	31.25	52 ± 18b	49	5.0 (1-6)a	142 ± 20e	87
	62.5	21 ± 7c	79	5.0 (4-5)b	129 ± 20a	29a
	125	95 ± 33	7	6.0 (5-6)	154 ± 10f	71
	250	80 ± 12	22	5.0 (4-7)	155 ± 16f	86

Results expressed as mean ± SD or median (minimum-maximum) of the parameters analyzed (n = 5-8). For the parametric data, mean ± SD was used, with ANOVA and a posteriori Dunnett’s test. For the non-parametric data, median (minimum-maximum) was used, with Kruskal-Wallis test and a posteriori Dunn.

^aP < 0.05,

^bP < 0.01 and

^cP < 0.001 vs colitic group;

^dP < 0.05,

^eP < 0.01 and

^fP < 0.001 vs non-colitic group. Cd: Combretum duarteanum; EtOHE: Ethanolic extract; HexP: Hexane phase.