Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation

Figure 6 MPO activity. Average of six readings is presented; One-way ANOVA followed by Dunnett’s multiple comparison test, and statistical significance was considered at ^aP < 0.05, ^bP < 0.01, ^eP < 0.001 vs disease control. HC: Healthy control; DC: Disease control; BBA: β-boswellic acid; SLZ: Sulfasalazine; BH: Prodrug of BBA with L-histidine; BP: Prodrug of BBA with D-phenylalanine; BT: Prodrug of BBA with L-tryptophan; BTY: Prodrug of BBA with L-tyrosine; H: L-histidine; P: D-phenylalanine; T: L-tryptophan; TY: L-tyrosine; BBA + H: Physical mixture of BBA + L-histidine; BBA + P: Physical mixture of BBA + D-phenylalanine; BBA + T: Physical mixture of BBA + L-tryptophan; BBA + TY: Physical mixture of BBA + L-tyrosine.