Esophagogastric junction distensibility assessed using the functional lumen imaging probe

Table 4 Achalasia subjects

Achalasia	Intervention (n)	Pre-treatment Distensibility1(mm2/mmHg)	Post-treatment Distensibility1(mm2/mmHg)	Pre-treatment CSA1(mm2)	Post-treatment CSA1(mm2)
20 mL bag volume
Pandolfino et al[10], 2013	Untreated (23)	Median 1.1 (5%-95% 0.9-1.6)	Median 1.8 (5%-95% 1.2-2.2)	N/A	N/A
	Treated2 (17)
Verlaan et al[20], 2013	10	Median 1.4 (IQR 1.1-2.4)	POEM: Median 3.0 (IQR 1.4-9.4)	N/A	N/A
30 mL bag volume
Familiari et al[9], 2014	POEM (21)	N/A	N/A	32.9 ± 23.1	102.38 ± 28.2
Teitelbaum et al[11], 2014	LHM (12)	LHM: 2.2 ± 1.7	LHM: 6.9 ± 3.3	N/A	N/A
	POEM (19)	POEM: 1.8 ± 1.4	POEM: 9.3 ± 4.1
Teitelbaum et al[12], 20133	LHM (11)	LHM: 1.7 ± 1.5	LHM: 6.7 ± 4.4	N/A	N/A
	POEM (14)	POEM: 1.8 ± 1.1	POEM: 8.2 ± 3.0
Rieder et al[8], 2013	POEM (4)	Median 0.8 (range 0.7-1.0)	Median 3.1 (range 1.7-3.4)	Median 22 (range 20-32)	Median 71.5 (range 30-106)
Pandolfino et al[10], 2013	Untreated (23)	Median 1.0 (5%-95% 0.8-1.2)	Median 2.5 (5%-95% 1.3-3.4)	N/A	N/A
	Treated2 (17)
Verlaan et al[20], 2013	10	Median 1.0 (IQR 0.8-1.5)	POEM: Median 2.9 (IQR 1.3-19.6)	N/A	N/A
40 mL bag volume
Rieder et al[8], 2013	POEM (4)	Median 1.0 (range 0.5-1.4)	Median 2.4 (range 1.1-3.0)	Median 41.5 (range 20-49)	Median 86 (range 41-137)
Teitelbaum et al[11], 2014	LHM (12)	LHM: 1.6 ± 1.0	LHM: 6.3 ± 3.4	N/A	N/A
	POEM (19)	POEM: 1.3 ± 1.0	POEM: 9.2 ± 3.9
Teitelbaum et al[12], 2014	LHM (20)	LHM: 1.5 ± 1.2	LHM 6.6 ± 3.1	N/A	N/A
	POEM (36)	POEM: 1.3 ± 1.4	POEM 8.3 ± 3.4
Teitelbaum et al[13], 20133	LHM (11)	LHM: 1.4 ± 1.3	LHM: 7.6 ± 4.4	LHM 33.5	LHM 163.6
	POEM (14)	POEM: 1.4 ± 1.9	POEM: 7.9 ± 2.7	POEM 38.8	POEM 163.3
Pandolfino et al[10], 2013	Untreated (23)	Median 0.7 (5%-95% 0.5-1.1)	Median 3.4 (5%-95% 2.2-4.9)	N/A	N/A
	Treated (17)
Verlaan et al[20], 2013	10	Median 1.1 (IQR 0.55-2.0)	POEM: Median 4.0 (IQR 2.9-12.7)	N/A	N/A
50 mL bag volume
Teitelbaum et al[11], 20133	LHM (11)	LHM: 1.1 ± 0.9	LHM: 5.7 ± 3.1	N/A	N/A
	POEM (14)	POEM: 1.4 ± 2.1	POEM: 6 ± 1.5
Rohof et al[19], 2012	7 Treated (6 PD, 1 LHM)	0.7 ± 0.9	4.4 ± 0.5	N/A	N/A
Verlaan et al[20], 2013	10	Median 1.0 (IQR 0.4-2.3)	POEM: Median 6.7 (IQR 3.8-16.6)	N/A	N/A

¹Values given in mean unless specified otherwise;

²Treated included patients that underwent pneumatic dilation, Heller myotomy with partial fundoplication, and POEM with good response;

³Subjects were included in the more recent Teitelbaum study (2014). CSA: Cross-sectional area; LHM: Laparoscopic Heller Myotomy; POEM: Peroral endoscopic myotomy; PD: Pneumatic dilation.