Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study

Table 2 Comparison of collagen fiber area, collagen I to collagen III ratio, hydroxyproline content, FactorVIII-positive cells and TGF-β1 expression among the three groups by Masson staining, immunohistochemistry, ELISA assay and immunofluorescent imaging

Group	No.	Collagen fiberarea		Collagen I to collagen III ratio		Hydroxyproline content (ng/mL)		FactorVIII-positivecells		TGF-β1expression
		mean ± SD1	P value	mean rank2	P value	mean ± SD1	P value	mean ± SD1	P value	mean ± SD1	P value
Healthy control	24	244679.38 ±	0.0203	38.854	0.0313	1693.72 ±	0.0133	23.25 ± 8.243	0.0003	93984.12 ±	0.0163
		210075.674				419.254				42066.644
Combination therapy (AT)	24	260909.51 ±		39.42		1909.53 ±		33.54 ± 8.72		101163.85 ±
		164713.88				828.78				38130.24
Monotherapy (AT)	24	135700.75 ±		25.963		1235.32 ±		28.58 ± 6.943		72321.44 ±
		94175.383				551.073				20030.293

¹ANOVA test was conducted because these data obey normal distributions;

²Kruskal-Wallis test was conducted because these data did not obey normal distributions;

³P values of post hoc comparison between groups were all lower than 0.05;

⁴P values between combination group and control group were higher than 0.05. AT: After treatment.