B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma

Table 1 Relationship between beta-2 adrenergic receptor expression and clinicopathological features

Clinicopathological features	n	B2A only area (μm2) mean ± SD	P value1	B2A only IOD mean ± SD	P value1
Gender
Male	38	25332.4 ± 15753.5	0.126	2861294.1 ± 1735364.6	0.109
Female	19	19450.2 ± 11703.5		3833335.5 ± 2431953.4
Age group
< 60	15	28796.9 ± 13781.3	0.085	4742202.6 ± 2372372.902	0.018a
≥ 60	42	21584.2 ± 14860.9		3086368.8 ± 2092543.9
Tumor size
< 5 cm	23	15778.7 ± 13661.5	0.003a	2463149.731 ± 2229187.1	0.008a
≥ 5 cm	25	28241.1 ± 13584.4		4188867.1 ± 2074271.4
CRC location
Right and transvers colon	9	24817.5 ± 19874.7	0.412	3818617.6 ± 3131069.5	0.375
Left colon, sigmoid and rectum	39	23347.2 ± 14047.3		3492859.3 ± 2140467.2
Gross appearance
Exophytic	20	23166.8 ± 14796.3	0.429	3260358.1 ± 2057001.7	0.208
Infiltrative, ulcero-infiltrative	28	24010.8 ± 15114.6		3852705.4 ± 2501409.4
Tumor invasion
T1-2	17	11110.3 ± 6784.4	0.000a	1650300.5 ± 1004078.8	0.000a
T3-4	31	36025.2 ± 8632.1		5433145.7 ± 1423440.9
Lymph node metastasis
N0-1	21	19264.3 ± 12628.1	0.010a	2904065.0 ± 1922977.6	0.013a
N≥ 2	27	30022.8 ± 15745.7		4498210.2 ± 2467186.4

¹Student t-test.

^aP < 0.05 statistically significant. IOD: Integrated optical density; B2A: Beta-2 adrenergic.