Dysregulation of mRNA profile in cisplatin-resistant gastric cancer cell line SGC7901

Table 4 Dysregulated mRNAs (P < 0.05, FC ≥ 2.0) associated with cisplatin resistance

Gene symbol	P value	FC (abs)	Regulation	Genename	Ref.
FGF7	0.00035	2.19252	Up	Fibroblast growth factor 7	PMID: 22990650
HIPK2	2.63E-06	4.06213	Up	Homeodomain interacting protein kinase 2	PMID: 24846322
EDN1	9.94E-05	2.46437	Up	Endothelin 1	PMID: 21220476
CBS	0.00108	2.29340	Up	Cystathionine-beta-synthase	PMID: 24236104
PDE3B	0.00029	10.44998	Up	Phosphodiesterase 3B, cgmp-inhibited	PMID: 24133626
E2F5	0.00041	2.42888	Up	E2F transcription factor 5, p130-binding	PMID: 22193543
PIN1	0.00104	2.13293	Up	Peptidylprolyl cis/trans isomerase, NIMA-interacting 1	PMID: 26820938
EGF	0.00346	4.76437	Up	Epidermal growth factor	PMID: 27086487
CSF1	0.00025	2.25620	Up	Colony stimulating factor 1 (macrophage)	PMID: 22005523
PCNA	0.00103	2.17028	Up	Proliferating cell nuclear antigen	PMID: 24474685
HIPK2	2.63E-06	4.06213	Up	Homeodomain interacting protein kinase 2	PMID: 24846322
ENTPD6	0.00011	2.43726	Up	Ectonucleoside triphosphate diphosphohydrolase 6 (putative)	PMID: 21519793
AKR1C1	0.00097	2.29646	Up	Aldo-keto reductase family 1, member C1	PMID: 23165153, PMID: 17266043
ASNS	0.00172	2.19491	Up	Asparagine synthetase (glutamine-hydrolyzing)	PMID: 23956056, PMID: 17409444
BDNF	0.00062	2.32411	Up	Brain-derived neurotrophic factor	PMID: 22276165, PMID: 17044982
CABYR	0.01089	2.55664	Up	Calcium binding tyrosine-(Y)-phosphorylation regulated	PMID: 24362251
FGF2	2.15E-06	2.99240	Up	Fibroblast growth factor 2 (basic)	PMID: 12894531
SLC7A11	1.95E-05	2.93256	Up	Solute carrier family 7 member 11	PMID: 24516043
TUBB3	0.00046	2.00213	Up	Tubulin, beta 3 class III	PMID: 25107571
TWIST1	0.00180	2.96340	Up	Twist family bhlh transcription factor 1	PMID: 22673193, PMID: 22245869
JAG1	9.41E-05	3.20086	Up	Jagged 1	PMID: 24659709
ANXA11	0.00031	2.36619	Down	Annexin A11	PMID: 19484149, PMID: 17982121
CCL5	2.67E-05	5.05630	Down	Chemokine (C-C motif) ligand 5	PMID: 26983899
FGF13	0.00044	17.08866	Down	Fibroblast growth factor 13	PMID: 24113164
IGFBP3	7.48E-05	2.92508	Down	Insulin-like growth factor binding protein 3	PMID: 20023704
KLK6	0.00066	2.24596	Down	Kallikrein-related peptidase 6	PMID: 23307575
SLC7A8	4.50E-05	5.36735	Down	Solute carrier family 7 member 8	PMID: 23462296
TGM2	2.88E-05	6.24520	Down	Transglutaminase 2	PMID: 21424127, PMID: 24828664
TLR4	0.00114	2.13271	Down	Toll-like receptor 4	PMID: 21616060, PMID: 22583829
XAF1	0.02405	3.20613	Down	XIAP associated factor 1	PMID: 25824780, PMID: 25240826
TCEA2	0.00061	3.65969	Down	Transcription elongation factor A (SII), 2	PMID: 16142353