Dysregulation of mRNA profile in cisplatin-resistant gastric cancer cell line SGC7901

Table 3 Cisplatin resistance pathway and input gene (P < 0.05, FC ≥ 2.0)

Pathway	Input gene	Fold change	Regulation	Genomic coordinates	Cyto band
PI3K-Akt signaling pathway	LAMA1	2.60826	Up	Chr18:6958512-6956742	hs|18p11.31
	LAMA1	2.75269	Up	Chr18:6942035-6941976	hs|18p11.31
	GNG4	2.09356	Up	Chr1:235714443-235714384	hs|1q42.3
	ITGB3	2.96629	Up	Chr17:45389027-45389086	hs|17q21.32
	ITGB6	7.72783	Up	Chr2:160964233-160958330	hs|2q24.2
	VEGFC	2.92538	Up	Chr4:177604882-177604823	hs|4q34.3
	PDGFD	2.42861	Up	Chr11:103778445-103778386	hs|11q22.3
	IRS1	2.00967	Up	Chr2:227596677-227596618	hs|2q36.3
	GNGT1	2.04779	Up	Chr7:93536149-93540155	hs|7q21.3
	CSF1	2.25620	Up	Chr1:110466137-110466196	hs|1p13.3
	EGF	4.76437	Up	Chr4:110932689-110932748	hs|4q25
	FGF2	3.02437	Up	Chr4:123819331-123819390	hs|4q28.1
	FGF2	2.99240	Up	Chr4:123819317-123819376	hs|4q28.1
	FN1	2.31254	Up	Chr2:216288895-216288217	hs|2q35
	COL4A6	2.08497	Up	Chrx:107399109-107399050	hs|Xq22.3
	FGF12	10.99211	Up	Chr3:191860574-191860515	hs|3q28
	GNG11	2.01984	Up	Chr7:93555764-93555823	hs|7q21.3
	FGF7	2.19252	Up	Chr15:49776810-49776869	hs|15q21.2
	LAMA3	2.56116	Down	Chr18:21534735-21534794	hs|18q11.2
	IFNA21	2.30808	Down	Chr9:21166331-21166272	hs|9p21.3
	CREB3L3	2.40183	Down	Chr19:4172219-4172278	hs|19p13.3
	TLR4	2.13271	Down	Chr9:120476856-120476915	hs|9q33.1
	COL6A2	2.89458	Down	Chr21:47546086-47546145	hs|21q22.3
	CD19	2.09302	Down	Chr16:28950600-28950659	hs|16p11.2
	LPAR5	3.83177	Down	Chr12:6728794-6728735	hs|12p13.31
	COL4A4	2.11177	Down	Chr2:227867523-227867464	hs|2q36.3
	PCK1	4.49558	Down	Chr20:56141030-56141089	hs|20q13.31
	VTN	3.82587	Down	Chr17:26694806-26694747	hs|17q11.2
	GNGT2	16.48365	Down	Chr17:47284034-47283975	hs|17q21.32
	IL2RG	2.87954	Down	Chrx:70328539-70328480	hs|Xq13.1
	COL5A3	7.53410	Down	Chr19:10070602-10070543	hs|19p13.2
	FGF13	17.08866	Down	Chrx:137713947-137713888	hs|Xq26.3
MAPK signaling pathway	FLNC	4.57879	Down	Chr7:128498538-128498597	hs|7q32.1
	FLNC	4.81302	Down	Chr7:128498476-128498535	hs|7q32.1
	CACNB2	7.83293	Down	Chr10:18787305-18787364	hs|10p12.31
	RASGRF1	4.87152	Down	Chr15:79254554-79254495	hs|15q25.1
	FOS	2.17501	Down	Chr14:75748214-75748273	hs|14q24.3
	JUN	2.04000	Down	Chr1:59246570-59246511	hs|1p32.1
	RASGRP2	3.10358	Down	Chr11:64508971-64508912	hs|11q13.1
	FGF13	17.08866	Down	Chrx:137713947-137713888	hs|Xq26.3
	TGFBR1	2.93035	Up	Chr9:101916322-101916381	hs|9q22.33
	TGFBR1	4.76437	Up	Chr4:110932689-110932748	hs|4q25
	EGF	4.76437	Up	Chr4:110932689-110932748	hs|4q25
	FGF12	10.99211	Up	Chr3:191860574-191860515	hs|3q28
	MAP3K13	2.25019	Up	Chr3:185161379-185165590	hs|3q27.2
	FGF2	3.02437	Up	Chr4:123819331-123819390	hs|4q28.1
	FGF2	2.99240	Up	Chr4:123819317-123819376	hs|4q28.1
	MAP2K7	2.08267	Up	Chr19:7979302-7979361	hs|19p13.2
	FGF7	2.19252	Up	Chr15:49776810-49776869	hs|15q21.2
	CACNG4	8.83585	Up	Chr17:65028139-65028198	hs|17q24.2
	CACNG4	2.94145	Up	Chr17:65029115-65029174	hs|17q24.2
	CACNB4	2.14311	Up	Chr2:152694239-152694180	hs|2q23.3
	GADD45A	2.56659	Up	Chr1:68153371-68153430	hs|1p31.3
	BDNF	2.32411	Up	Chr11:27679959-27679900	hs|11p14.1
	BDNF	2.30323	Up	Chr11:27677072-27677013	hs|11p14.1
	CACNA2D1	2.09452	Up	Chr7:81579504-81579445	hs|7q21.11
Notch signaling pathway	MAML2	2.03379	Up	Chr11:95712434-95712375	hs|11q21
	JAG1	3.20086	Up	Chr20:10619120-10619061	hs|20p12.2
	MAML3	2.57919	Up	Chr4:140810806-140810747	hs|4q31.1
	DTX4	9.99859	Down	Chr11:58975615-58975674	hs|11q12.1
ErbB signaling pathway	EGF	4.76437	Up	Chr4:110932689-110932748	hs|4q25
	NRG1	2.77996	Up	Chr8:32474390-32585512	hs|8p12
	MAP2K7	2.08267	Up	Chr19:7979302-7979361	hs|19p13.2
	JUN	2.04000	Down	Chr1:59246570-59246511	hs|1p32.1
	ERBB3	5.29571	Down	Chr12:56482380-56482439	hs|12q13.2
	ERBB3	8.12050	Down	Chr12:56496160-56496219	hs|12q13.2
	TGFA	2.37427	Down	Chr2:70675378-70675319	hs|2p13.3
Jak-STAT signaling pathway	IL11	4.21849	Up	Chr19:55875847-55875788	hs|19q13.42
	IL15	2.92970	Up	Chr4:142654431-142654490	hs|4q31.21
	SOCS2	2.00180	Up	Chr12:93969799-93969858	hs|12q22
	SPRY1	5.95682	Up	Chr4:124324494-124324553	hs|4q28.1
	LEPR	2.90187	Up	Chr1:66102129-66102188	hs|1p31.3
	IL2RG	2.87954	Down	Chrx:70328539-70328480	hs|Xq13.1
	MPL	3.41581	Down	Chr1:43819826-43819885	hs|1p34.2
NF-kappaB signaling pathway	CXCL2	2.03846	Up	Chr4:74963044-74962985	hs|4q13.3
	CXCL8	9.97781	Up	Chr4:74609265-74609324	hs|4q13.3
	TLR4	2.13271	Down	Chr9:120476856-120476915	hs|9q33.1
HIF-1 signaling pathway	EDN1	2.39081	Up	Chr6:12296672-12296731	hs|6p24.1
	EDN1	2.46437	Up	Chr6:12296218-12296277	hs|6p24.1
	EGF	4.76437	Up	Chr4:110932689-110932748	hs|4q25
	TLR4	2.13271	Down	Chr9:120476856-120476915	hs|9q33.1
MicroRNAs in cancer	IRS1	2.00967	Up	Chr2:227596677-227596618	hs|2q36.3
	ZEB2	3.32563	Up	Chr2:145146320-145146261	hs|2q22.3
	ZEB2	2.70558	Up	Chr2:145182422-145182363	hs|2q22.3
	CD44	2.02409	Up	Chr11:35253812-35253871	hs|11p13
	RECK	2.25018	Up	Chr9:36124319-36124378	hs|9p13.3
	ITGB3	2.96629	Up	Chr17:45389027-45389086	hs|17q21.32
	SERPINB5	2.61864	Up	Chr18:61172218-61172277	hs|18q21.33
	GLS	2.36144	Up	Chr2:191829716-191829775	hs|2q32.2
	GLS	2.07371	Up	Chr2:191827822-191827881	hs|2q32.2
	ERBB3	5.29571	Down	Chr12:56482380-56482439	hs|12q13.2
	ERBB3	8.12050	Down	Chr12:56496160-56496219	hs|12q13.2