Dysregulation of mRNA profile in cisplatin-resistant gastric cancer cell line SGC7901

Table 2 Different expressed mRNAs enriched by KOBAS

Term	Database	P value	Input gene symbols
Gastric cancer	KEGG DISEASE	0.0016	DCC, CD44, CDH1, VEGFC, EGF, TGFA
Skin diseases	KEGG DISEASE	0.0078	DSP, TGM1, CCL5, IL31RA, SPINK5, HLA, FERMT1, KRT14, CTSC, COL17A1, LAMA3, REEP1, RIN2, ALOXE3, ABCC6, WNT10A, FBLN5
Skin and soft tissue diseases	KEGG DISEASE	0.0078	DSP, TGM1, CCL5, IL31RA, SPINK5, HLA, FERMT1, KRT14, CTSC, COL17A1, LAMA3, REEP1, RIN2, ALOXE3, ABCC6, WNT10A, FBLN5
Macular degeneration	KEGG DISEASE	0.0140	C3, FBLN5, CFH, TLR4
Cancers of the digestive system	KEGG DISEASE	0.0439	DCC, CD44, CDH1, VEGFC, EGF, TGFA
Familial thoracic aortic aneurysm and dissection (TAAD)	KEGG DISEASE	0.0459	MYLK, TGFBR1
Hypomagnesemia	KEGG DISEASE	0.0459	TRPM6, EGF
Multiple epiphyseal dysplasia (MED)	KEGG DISEASE	0.0459	COL9A3, MATN3
Transient neonatal diabetes mellitus (TNDM)	KEGG DISEASE	0.0459	PLAGL1, ZFP57
Non-syndromic autosomal dominant mental retardation	KEGG DISEASE	0.0461	EPB41L1, DOCK8, PACS1, SMARCA4
Cardiac hypertrophy	NHGRI GWAS Catalog	0.0028	PLXNA2, GRIK2, COL17A1, JAG1, SNAP25, BTBD3, SLX4IP
Response to fenofibrate (adiponectin levels)	NHGRI GWAS Catalog	0.0046	OAS2, PMEPA1, SHANK2, SCUBE1, SLC30A4, PCK1
Complement C3 and C4 levels	NHGRI GWAS Catalog	0.0094	HLA, CFHR3, CFH, C3
Neutrophil count	NHGRI GWAS Catalog	0.0119	PLCB4, TGFA, FGGY, PDGFD, PSD3
Nephropathy(idiopathic membranous)	NHGRI GWAS Catalog	0.0137	HLA, ITGB6, PLA2R1
Sleep duration	NHGRI GWAS Catalog	0.0195	PLLP, TMC5, ADAMTS14
Airflow obstruction	NHGRI GWAS Catalog	0.0259	HYKK, LEF1, SERPINB8, GPR126, MAP3K13, PTPRD
Cystic fibrosis severity	NHGRI GWAS Catalog	0.0265	HLA, EHF, AHRR
Metabolite levels (5-HIAA/ MHPG Ratio)	NHGRI GWAS Catalog	0.0265	PIEZO2, ROBO2, ADAM12
Bronchopulmonary dysplasia	NHGRI GWAS Catalog	0.0296	PLXDC2, ZNF770, SPOCK1, TRPS1, RASGRF1, HIVEP3
Major depressive disorder	NHGRI GWAS Catalog	0.0346	PCLO, SLC6A15, ENOX1, SYPL2, IGFBP1, IGFBP3, C12orf5, ATXN1, PIEZO2, TRPS1, RASGEF1B, FGF12, KCNH5
IgA nephropathy	NHGRI GWAS Catalog	0.0346	HLA, ACOXL, TNFSF13
Pulmonary function decline	NHGRI GWAS Catalog	0.0368	MUSK, CSMD1, RORA, FLRT2
Palmitic acid (16:0) plasma levels	NHGRI GWAS Catalog	0.0368	SCD, CNN3, GRIK2, PTPRD
Male-pattern baldness	NHGRI GWAS Catalog	0.0439	AUTS2, EDA2R, AR
Response to citalopram treatment	NHGRI GWAS Catalog	0.0439	LAMA1, RORA, EGFLAM
Hyperlipidemia	FunDO	0.0050	IRS1, CCL5, C3, PAPPA, TXNIP, APOC1, F3, SCD
Thrombocytopenia	FunDO	0.0068	GATA1, CCL5, ITGB3, IL11, CXCL8, MPL
Fibromyalgia	FunDO	0.0126	MAOB, CXCL8, BDNF, IGFBP3
Cirrhosis	FunDO	0.0209	RBP4, KRT18, IGFBP3, KRT8, EGF, F3, FGF2IGFBP1
Hepatitis C	FunDO	0.0321	CD274, CCL5, RBP4, MKI67, CXCL8, KRT18, TLR4, KRT8, FGF2
Thalassemia	FunDO	0.0345	LCN2, CXCL8, ANK2, KIR3DL1, MUC1
Gingival overgrowth	FunDO	0.0417	EDN1, IL15, FGF7
Pulmonary fibrosis	FunDO	0.0474	CSF1, BDNF, MMP7, EDN1, CCL5, ERBB3
Ovary cancer	FunDO	0.0477	LCN2, IL15, CXCL8, FGF7, CASP1
Esophageal tumor	FunDO	0.0477	CD274, TSPAN8, FRAT1, PDCD1LG2, FGF7
Hyperlipidemia	GAD	0.0093	CCL5, HLA, CXCL8, CD22, TNFRSF1B, CD19
Thrombocytopenia	GAD	0.0114	CSMD1, DOCK4, GALNTL6, SOBP, PLXDC2, SESN3, ADAMTS5, EHF, TMC5, LPL, CD109, FAM117B, PDE1C, TAGLN, PTN, FGD4, DYNC2H1, GNG4, MUSK, FBLN5, CCDC54, TTC9, PMEPA1, TLR4, ANK3, EDA2R, APOC1, BMP2, TOX3, NRG1, ITPK1, PTPRD, KLF6, PAM, PTPRU, LEPR, IKZF2, LHX5, MCTP2, ANKRD50, SEMA6D, PLXNA2, DPYD, GRIK2, SRGAP3, ACOXL, TDRKH, FAM135B, VEGFC, CHST2
Fibromyalgia	GAD	0.0136	GLI3, CELF2, VWA3B, PLXDC2, EDNRA, EDN1, JUN, DOCK8, DCLK2, BTBD3, DCN, CD74, EGFLAM, TLL1, TLR4, BMP2, PTPRD, ANK2, PTPRU, JADE2, IGF2BP2, PAPPA, DOCK2, KLK4, FAM49A, RGS3, AATK, FN1, IGSF10, NCOA7, SCIN, TNS1, FAM135B, MUC16, ADAM19, ATXN1, MTUS2, NXNL2, KCNQ3, ANPEP, CDH2
Cirrhosis	GAD	0.0204	IRS1, CCL5, ITGB3, NPR1, NPR3, APOC1, LPL
Hepatitis C	GAD	0.0258	DPYD, CELF4, CELF2, FAM117B, TDRKH, LPCAT4, FBLN5, SOBP, PMEPA1, CSMD1, STOX1, CACNB2, CADM1, VEGFC, SLC7A11, LPL, CD109, MCTP2, SLC24A2, PTPRD, ITPK1
Thalassemia	GAD	0.0362	MCTP2, PSD3, CCDC54, ROBO2, ELOVL6
Gingival overgrowth	GAD	0.0419	PLXNA2, ATXN1, IGF2BP2, ABCA13, FN1
Pulmonary fibrosis	GAD	0.0420	CREG2, GALNTL6, LINC01550, KIF16B, SH3BGR, TRPS1, PDE1C, NCKAP5, TNFRSF21, RYR3, MAGEC2, EDIL3, CXCL16, MCF2, DTD1, GPC5, KLF6, IKZF2, KCNH5, AJAP1, BTBD3, PHACTR2, ITPK1, IGSF10, SRGAP3, C12orf75, ABI3BP, FOS, SCUBE1
Ovary cancer	GAD	0.0426	CELF4, TRPS1, TWIST1, PQLC2L, MAL2, PSD3, RCAN2, SUPT3H, TGFA, TMEM131L, HIVEP3, CSMD1, ROBO2, CCDC54, PRNP, APOC1, HRK, GPC5, AR, FN1, ABCA13, F2RL2, KLF6, IGF2BP2, LEPREL1, GNG4, SNAP25, MCTP2, FAM49A, ANKRD50, CACNA2D1, PLXNA2, ELOVL6, RUNX2, SCN8A, ATXN1, ID2, SLC24A2, CMTM7, LINGO2
Esophageal tumor	GAD	0.048	CACNA2D1, SLC46A3, CHST2, PKDCC, PPID, CDH2