Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation

Table 1 Doses of test and standard drugs

Compound	Dose1 in mg/kg	Compound	Dose1 in mg/kg
HC	0.9 % saline (1 mL)	P	759
BBA	2159	T	938
SLZ	300	TY	832
BH	2795	BBA + H	2871
BP	2841	BBA + P	2918
BT	3020	BBA + T	3097
BTY	2914	BBA + TY	2991
H	712

¹All doses are calculated on an equimolar basis to the dose of BBA. HC: Healthy control; BBA: β-boswellic acid; SLZ: Sulfasalazine; BH: Prodrug of BBA with L-histidine; BP: Prodrug of BBA with D-phenylalanine; BT: Prodrug of BBA with L-tryptophan; BTY: Prodrug of BBA with L-tyrosine; H: L-histidine; P: D-phenylalanine; T: L-tryptophan; TY: L-tyrosine; BBA + H: Physical mixture of BBA + L-histidine; BBA + P: Physical mixture of BBA + D-phenylalanine; BBA + T: Physical mixture of BBA + L-tryptophan; BBA + TY: Physical mixture of BBA + L-tyrosine.