Coexisting tubular adenoma with a neuroendocrine carcinoma of colon allowing early surgical intervention and implicating a shared stem cell origin

Figure 2 Hematoxylin and eosin staining of the tumor sections at × 2000 (A) and × 20000 (B). A: Shows the tubular adenoma component juxtaposed to the underlying high-grade large-cell neuroendocrinal carcinoma; B: Higher magnification showing medium to large-sized tumor cells with vesicular nuclei, prominent nucleoli consistent with large-cell neuroendocrine carcinoma.