Modified docetaxel, cisplatin and capecitabine for stage IV gastric cancer in Japanese patients: A feasibility study

Table 3 Previous reports regarding docetaxel, cisplatin and capecitabine

Ref.	Setting	Capecitabine	Cisplatin	Docetaxel	Interval (d)	Number of patients		Grade 3-4 neutropenia	Febrile neutropenia	RR (95%CI)	PFS (95%CI)	OS (95%CI)	R0 resection	pCR
											(mo)	(mo)
Kang et al[10], 2010	Metastatic or recurrent	1875 mg, days 1-14	60 mg, day 1	60 mg, day 1	21	40		62.5%	10%	68% (53%-83%)	7.6 (6.9-8.4)	14.4 (7.3-21.5)		10.0%
Sym et al[17], 2010	Neoadjuvant	1875 mg, days 1-14	60 mg, day 1	60 mg, day 1	21	49 (36 resected cases)		69%	4%		R0: 54.3 (0-112.9)	R0: not reached	63.0%
											Non-R0: 5.1 (3.6-6.6)	Non-R0: 11.5 (7.3-15.7)
Thuss-Patience et al[12], 2012	Perioperative	1875 mg, days 1-14	60 mg, day 1	75 mg, day1	21	51	Preoperative	76.5%	21.5%				90.2%	13.7%
							Postoperative	62.9%	11.1%
Polyzos et al[16], 2012	Metastatic	2000 mg, days 2-15	60 mg, day 1	60 mg, day 1	21	36		50%	16%	44.4% (28%-60%)	5 (3-6)1	12 (5-24)
Yoon et al[18], 2015	Adjuvant for stage IIIB-IV	1875 mg, days 1-14	60 mg, day 1	60 mg, day 1	21	46		40%	15%		26.9 (7.5-46.4)2	43.9 (29.2-58.7)

¹Time to progression;

²Relapse-free survival. RR: Response rate; PFS: Progression-free survival; OS: Overall survival; pCR: Pathological complete response.