Is a split-dose regimen of 2 L polyethylene glycol plus ascorbic acid tolerable for colonoscopy in an early morning visit to a comprehensive medical check-up?

Table 5 Subjective discomfort of patients according to different preparation regimens n (%)

	Non-split-dose regimen	Split-dose regimen	P value
	n = 189	n = 189
Discomfort score (0-10)1	5.2 ± 2.7	4.8 ± 2.8	0.257
Willingness to repeat same regimen
Yes	132 (69.8)	133 (70.4)	0.243
No	47 (24.9)	52 (27.5)
Adverse events
Poor taste	53 (50.5)	74 (54.0)	0.585
Nausea/vomiting	39 (37.1)	53 (38.7)	0.806
Bloating	38 (36.2)	54 (39.4)	0.608
Excessive diarrhea	27 (25.7)	27 (19.7)	0.266
Anal pain	20 (19.0)	14 (10.2)	0.050
Abdominal pain/discomfort	13 (12.4)	20 (14.6)	0.618
Dizziness	9 (8.6)	9 (6.6)	0.556
Fecal incontinence	8 (7.6)	7 (5.1)	0.422
Sleep disturbance	6 (5.7)	56 (40.9)	< 0.001
Bulky fluid	4 (3.8)	0 (0)	0.021
Chilling	3 (2.9)	1 (0.7)	0.198
Headache	1 (1.0)	0 (0)	0.252

¹Patients graded subjective discomfort from 0 (tolerable) to 10 (extremely distressed).