Early thrombomodulin-α administration outcome for acute disseminated intravascular coagulopathy in gastrointestinal surgery

Table 4 Survival analysis at 28 d after thrombomodulin-α administration

Factor		n = 31	28-d survival rate	P value
Sex	Male	22	73%	0.83
	Female	9	67%
Age	≤ 70	14	64%	0.54
	> 70	17	76%
Duration of administration	≥ 4, ≤ 6	16	88%	0.03
	≤ 3, ≥ 7	15	53%
Initiation of administration after DIC (d)	≤ 1	27	74%	0.43
	≥ 2	4	50%
DIC scores before the treatment	≤ 5	21	67%	0.52
	≥ 6	10	80%
Improvement in DIC scores at 1 wk	≤ 3	14	93%	0.01
	≥ 4	17	53%
SIRS scores before the treatment	≤ 2	12	58%	0.2
	≥ 3	19	79%
Improvement in SIRS scores at 1 wk	≤ 2	21	86%	0.09
	≥ 3	7	57%
qSOFA scores before the treatment	≤ 1	11	73%	0.8
	≥ 2	20	70%
Improvement in qSOFA scores at 1 wk	≤ 1	22	91%	0.001
	≥ 2	6	33%
Sepsis	Present	20	70%	0.8
	Absent	11	73%
Shock	Present	16	81%	0.24
	Absent	15	60%
Lactate values before the treatment	≥ 2	8	75%	0.69
	< 2	18	83%

DIC: Disseminated intravascular coagulopathy; qSOFA: Quick-sequential organ failure assessment; SIRS: Systemic inflammatory response syndrome.