Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma

Table 1 Association between demographics and hepatitis B surface antigen status among relatives of patients with hepatocellular carcinoma n (%)

Category	HBsAg		OR (95%CI)	Adjusted OR (95%CI)1
	Positive	Negative
Total family members	314	415
Sex
Male	171 (54.46)	196 (47.23)	1.25 (0.97-1.61)
Female	143 (45.54)	219 (52.77)
Index sex
Male	229 (72.93)	302 (72.77)	1.07 (0.70-1.62)	1.25 (0.97-1.60)
Female	85 (27.07)	113 (27.23)
Age, mean ± SD	40.49 ± 10.89	37.87 ± 11.69	1.01 (1.00-1.03)	1.28 (1.00-1.64)
Relation to index
Parent	10 (3.18)	20 (4.82)	0.78 (0.37-1.64)	0.81 (0.38-1.71)
Index generation	86 (27.39)	36 (8.67)	3.89 (2.32-6.51)a	3.97 (2.38-6.63)a
Child	206 (65.61)	347 (83.61)
Grandchild	12 (3.82)	12 (2.89)	1.43 (0.66-3.13)	1.39 (0.65-3.00)
Maternal HBsAg
Negative	86 (27.38)	244 (58.80)
Positive	129 (41.08)	53 (12.77)	5.03 (3.16-8.01)a	5.00 (3.13-7.97)a
Unknown	99 (31.53)	118 (28.43)	2.01 (1.30-3.38)a	2.04 (1.33-3.13)a
Index HBsAg2
Negative	48 (15.43)	203 (49.03)
Positive	263 (84.57)	211 (50.97)	5.57 (3.56-8.71)a	5.51 (3.53-8.61)a

¹Adjusted by sex;

²Four index cases. HBsAg status unknown.

^aP < 0.0001. HBsAg: Hepatitis B surface antigen.