Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding

Figure 4 Representative two-parameter dot plots showing only the cells gated for CD4⁺ T and CD20⁺ B cells from the peripheral bloods of individuals carrying the TBX21-1993TC and -1993TT genotypes. The y-axis of each histogram represents the specific fluorescence of extracellular CD69-phycoerythrin (PE) (T lymphocytes) and CD27-PE (B lymphocytes). The x-axis represents the specific fluorescence of Alexa-Flour 647-T-bet, FITC-IFNγ, or Cy5.5-IFN-γ on four-decade logarithmic scales. The quadrants were assigned using appropriate isotype controls for each intra- and extracellular antibody. A: AIH-1 patients; B: Healthy controls.