Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights

Figure 21 IC + OB rats. Per cent of vessels present between arcade vessels, next to the proximal ligature (arcade 0), next to the distal ligature (arcade 4), and within the ligation (arcade 1, 2, 3) on the dorsal side of the colon at 15 min after therapy (as 100%); mean ± SD. The gross presentation was recorded using a USB microscope camera. After additional colon obstruction for three days, BPC 157 (10 μg/kg, 1 mL bath/rat) or an equal volume of a saline bath was applied to the 25-mm blood-flow-deprived colon segment 1 min after the colon obstruction was removed. The rats were sacrificed 15 min later, and the following time points were assessed: A: after ligation and before therapy (1 min); B: 5 min after the application of medication; C: between 5 and 10 min after the application of medication; D: from 10 min after the application of medication until the end of the observation at 15 min. For clarity, the SD is not shown on the graph; the SD was never higher than 10% of the mean. ^aP < 0.05 at least vs control.