Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights

Figure 5 IC rats. Per cent of vessels present between arcade vessels next to the proximal (arcade 0) and distal (arcade 4) ligatures and within the ligated area (arcade 1, 2, 3) on the dorsal side of the colon at 15 min following therapy (as 100%); mean ± SD. The gross appearance of the tissue was recorded using a USB microscope camera. The following time points were assessed: A - after ligation and before therapy (1 min); B - 5 min after the application of medication; C - between 5 and 10 min after the application of medication; D - from 10 min after the application of medication until the end of the observation at 15 min. At 1 min post-injury, medication (/kg, 1 ml bath/rat) consisting of BPC 157 (10 µg), the NOS blocker L-NAME (5 mg) and the NOS substrate L-arginine (100 mg) alone or combined, or an equal volume of a saline bath (controls) was applied to the 25-mm blood-flow-deprived colon segment; the rats were sacrificed at 15 minutes. For clarity, the SD is not shown on the graph; the SD was never higher than 10% of the mean. ^aP < 0.05 at least vs control.