Multicenter, randomized study to optimize bowel preparation for colon capsule endoscopy

Table 1 Bowel preparation regimens

Time	Study regimen	Control regimen
2 d prior	≥ 2400 mL (10 glasses) of liquid during the day; 4 senna tablets at bedtime
1 d prior	Clear liquid diet all day; 2 L sulfate-free PEG-ELS1 at about 7-9 pm (one 237 mL-296 mL cup (8-10 oz. cup) every 10-15 min)
Day of capsule procedure
45-75 min prior to capsule ingestion	2 L sulfate-free PEG-ELS
1 h after capsule ingestion	Optional prokinetics (only if capsule in stomach > 1 h): 10 mg metoclopramide or 250 mg erythromycin
1st boost: After capsule entry into small bowel2	89 mL (3 oz) OSS plus 60 mL diatrizoate solution1	89 mL (3 oz.) OSS
2nd boost: 3 h after 1st boost, only if capsule not excreted	89 mL (3 oz) OSS plus 30 mL diatrizoate solution1	89 mL (3 oz.) OSS
3rd boost: 2 h after 2nd boost, only if capsule not excreted	10 mg bisacodyl suppository
2 h after 3rd boost, or after capsule passes (whichever occurs first)	Standard full meal

¹Diatrizoate solution = diatrizoate meglumine and diatrizoate sodium solution;

²Clear liquids permitted after ingestion of 1^st boost, PEG-ELS: Polyethylene glycol-electrolyte solution; OSS: Oral sulfate solution.