Analysis of 12 variants in the development of gastric and colorectal cancers

Table 4 Genotypic and allelic distributions of the investigated polymorphisms for patients with colorectal cancer in comparison to control group

Genotype	CRC	Control	P value1	OR (95%CI)a	Genotype	CRC	Control	P-value1	OR (95%CI)1
CASP8	63	475			RP2/RP2	16 (25.4)	154 (32.5)	0.871	1.068 (0.482-2.368)
DEL/DEL	13 (20.6)	90 (19.0)	0.676	0.888 (0.508-1.552)	Allele RP1	0.44	0.41
INS/DEL	28 (44.4)	230 (48.4)			Allele RP2	0.56	0.59
INS/INS	22 (35.0)	155 (32.6)	0.939	0.974 (0.503-1.887)	NFKB1	63	473
Allele DEL	0.43	0.43			DEL/DEL	16 (25.4)	117 (24.7)	0.0062	3.732 (1.451-9.599)
Allele INS	0.57	0.57			INS/DEL	42 (66.7)	246 (52.0)
MDM2	64	475			INS/INS	5 (7.9)	110 (23.3)	0.829	0.935 (0.508-1.723)
DEL/DEL	7 (10.9)	33 (6.9)	0.412	1.166 (0.143-9.487)	Allele DEL	0.60	0.51
INS/DEL	25 (39.1)	168 (35.4)			Allele INS	0.40	0.49
INS/INS	32 (50.0)	274 (57.7)	0.986	0.995 (0.546-1.811)	PAR1	63	473
Allele DEL	0.30	0.25			DEL/DEL	37 (58.7)	273 (57.7)	0.464	0.704 (0.275-1.801)
Allele INS	0.70	0.75			INS/DEL	20 (31.8)	169 (35.7)
TP53	64	475			INS/INS	6 (9.5)	31 (6.6)	0.813	0.937 (0.546-1.608)
DEL/DEL	47 (73.4)	350 (73.7)	0.886	1.166 (0.143-9.487)	Allele DEL	0.75	0.76
INS/DEL	16 (25.0)	116 (24.4)			Allele INS	0.25	0.24
INS/INS	1 (1.6)	9 (1.9)	0.986	0.995 (0.546-1.811)	CYP2E1	62	475
Allele DEL	0.86	0.86			DEL/DEL	56 (90.3)	398 (83.8)	0.999	189364591.0 (0.000)
Allele INS	0.14	0.14			INS/DEL	6 (9.7)	73 (15.4)
TYMS	63	475			INS/INS	0 (0.0)	4 (0.8)	0.351	0.655 (0.269-1.593)
DEL/DEL	11 (17.5)	65 (13.7)	0.304	1.342 (0.765-2.354)	Allele DEL	0.95	0.91
INS/DEL	31 (49.2)	224 (47.2)			Allele INS	0.05	0.09
INS/INS	21 (33.3)	186 (39.2)	0.429	0.751 (0.369-1.526)	CYP19A1	64	475
Allele DEL	0.42	0.37			DEL/DEL	7 (10.9)	76 (16.0)	0.297	0.747 (0.431-1.293)
Allele INS	0.58	0.63			INS/DEL	33 (51.6)	248 (52.2)
XRCC1	64	474			INS/INS	24 (37.5)	151 (31.8)	0.313	1.532 (0.669-3.508)
DEL/DEL	4 (6.2)	35 (7.4)	0.771	1.082 (0.637-1.838)	Allele DEL	0.37	0.42
INS/DEL	27 (42.2)	179 (37.8)			Allele INS	0.63	0.58
INS/INS	33 (51.6)	260 (54.8)	0.445	1.528 (0.515-4.535)	UGT1A1	63	464
Allele DEL	0.27	0.26			*1/*1	20 (31.7)	206 (44.5)	0.098	0.541 (0.262-1.120)
Allele INS	0.73	0.74			*1/*28	32 (50.8)	209 (45.0)
IL1A	64	475			*28/*28	6 (9.5)	46 (9.9)	0.370	1.282 (0.745-2.205)
DEL/DEL	10 (15.6)	86 (18.1)	0.657	0.880 (0.500-1.548)	*36/*1	3 (4.8)	3 (0.6)
INS/DEL	33 (51.6)	246 (51.8)			*36/*37	1 (1.6)	0 (0.0)	0.0012	12.849 (2.906-56.817)
INS/INS	21 (32.8)	143 (30.1)	0.610	1.208 (0.584-2.368)	*1/*37	1 (1.6)	0 (0.0)
Allele DEL	0.41	0.44			Allele *36	0.03	0.01
Allele INS	0.59	0.56			Allele *1	0.60	0.67
IL4	63	474			Allele *28	0.35	0.32
RP1/RP1	8 (12.7)	69 (14.5)	0.195	1.493 (0.814-2.740)	Allele *37	0.02	0.00
RP1/RP2	39 (61.9)	251 (53.0)

Data for CRC and Control columns are presented as n or n (%).

¹Analysis of combined genotypes (INS/INS vs others, or DEL/DEL vs others) with adjusted values for confounding factors (European and African ancestries) in logistic regression;

²Statistically significant. CRC: Colorectal cancer; INDEL: Insertion/deletion.