Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights

doi:10.3748/wjg.v23.i48.8465

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Dec 28, 2017 (publication date) through May 6, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2017; 23(48): 8465-8488
Published online Dec 28, 2017. doi: 10.3748/wjg.v23.i48.8465

Table 3 Assessment of lesions in rats with obstruction of the left colic artery and vein for 10 d via two ligations; the animals underwent additional colon obstruction for the first 3 d

Medication (/kg, 1 ml bath/rat) at the 25-mm blood-flow- deprived colon segment	Pale areas without mucosal folds as a percentage of the entire area of the blood-deprived colon segment means ± SD	Number of gross mucosal defects,mean ± SD	Colon diameter,mean ± SD	Adhesion severityscored 0-2,Min/Med/Max
0.9% NaCl (control)	125 ± 10	4 ± 1	36 ± 8	2/2/2002
BPC 157 (10 µg)	10 ± 2^a	0 ± 0^a	9 ± 1^a	0/1/1^a

They received BPC 157 or saline bath on day 3, immediately after the additional colon obstruction was removed. The animals were assessed one week thereafter, on day 10 after ligation. Pale flat areas without mucosal folds were measured and are expressed as the percentage of the entire area of the blood-deprived colon segment (mean ± SD). Number of gross mucosal defects; mean ± SD; colon diameter, mean ± SD; adhesion severity, scored 0-2 (Min/Med/Max, respectively).

^aP < 0.05 at least vs control.

Citation: Duzel A, Vlainic J, Antunovic M, Malekinusic D, Vrdoljak B, Samara M, Gojkovic S, Krezic I, Vidovic T, Bilic Z, Knezevic M, Sever M, Lojo N, Kokot A, Kolovrat M, Drmic D, Vukojevic J, Kralj T, Kasnik K, Siroglavic M, Seiwerth S, Sikiric P. Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights. World J Gastroenterol 2017; 23(48): 8465-8488
URL: https://www.wjgnet.com/1007-9327/full/v23/i48/8465.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i48.8465