Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model

Figure 4 Effect of oral gavage of fructo-oligosaccharide on short chain fatty acid concentrations. The average concentrations of total SCFA, acetic, propionic, and butyric acids increased in FOS-administered mice compared to saline-administered mice following WAS intervention. No difference was observed in total SCFA, acetic, propionic, and butyric acid levels with FOS or saline administration in mice following sham-WAS. Values represent mean ± SD; sham + saline (n = 7), sham + FOS (n = 7), WAS + saline (n = 6), WAS + FOS (n = 7); one-way ANOVA. ^aP < 0.05, WAS + saline vs WAS + FOS. SCFA: Short chain fatty acids; FOS: Fructo-oligosaccharide; WAS: Water avoidance stress.