Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis

Figure 1 Efficacy of Panax notoginseng in experimental colitis was dependent on initial time of administration. A: PN administration (1.0 g/kg) was initiated at day 3 and 7 for seven consecutive days; B, C, G, J: DAI scores and serum concentrations of TNF-α and IL-6 in the day 3 group were significantly lower than those in the day 7 group; D, E: The pathological lesions of colonic mucosa and microvessels in the day 3 group were less than those in the day 7 group; F: MVD in the day 3 group was significantly higher than that in the day 7 group. Results are expressed as mean ± SD of three independent experiments performed in triplicate. ^aP < 0.05, ^bP < 0.01 vs normal control. DAI: Disease activity index; IL: Interleukin; MVD: Microvessel density; PN: Panax notoginseng; TNF: Tumor necrosis factor.