Nomogram based on tumor-associated neutrophil-to-lymphocyte ratio to predict survival of patients with gastric neuroendocrine neoplasms

Table 4 Variables associated with overall survival according to the Cox proportional hazards regression model

Variable	Univariate analysis			Multivariate analysis
	Hazard ratio	95%CI	P value	Hazard ratio	95%CI	P value
Age (yr)			0.566
≤ 70	Reference
> 70	1.197	0.648- 2.211
Gender			0.190
Male	Reference
Female	0.640	0.329-1.247
Tumor site			0.190
Upper	Reference
Middle	0.687	0.313-1.509
Lower	0.540	0.255-1.145
Mixed	1.441	0.628-3.307
Tumor size (cm)			0.002			0.214
≤ 3.5	Reference			Reference
> 3.5	3.591	1.618-7.969		NA	NA
Lymphovascular invasion			0.214
No	Reference
Yes	1.417	0.818-2.455
ASA status			0.118
1 + 2	Reference
3 + 4	1.736	0.870-3.465
Postoperative complication			0.320
No	Reference
Yes	1.380	0.732-2.603
Surgical approach			0.276
Endo/laparoscopic	Reference
Open	0.736	0.425-1.276
Depth of invasion			0.024			0.646
T1	Reference			Reference
T2	5.524	0.501-60.954		NA	NA
T3	10.793	1.455-80.038		NA	NA
T4	15.632	2.116-115.464		NA	NA
Lymph node ratio			< 0.001			0.002
0	Reference			Reference
> 0, ≤ 0.2	4.791	1.402-16.370		2.854	0.813-10.027
> 0.2, ≤ 0.4	6.676	1.956-22.790		3.724	1.054-13.162
> 0.4	14.677	4.218-51.074		9.152	2.528-33.129
Ki-67 index (%)			0.002			< 0.001
≤ 2%	Reference			Reference
≥ 3%, ≤ 20%	2.168	0.437-10.751		1.584	0.313-8.008
> 20%	6.582	1.589-27.269		5.535	1.238-24.752
TA-NLR			< 0.001			0.003
≤ 0.21	Reference			Reference
> 0.21	2.938	1.610-5.360		2.617	1.389-4.928

TA-NLR: Tumor-associated neutrophil-to-lymphocyte ratio.