Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease

Table 5 Allelic frequencies of (CCTTT)n microsatellite polymorphism of NOS2A gene for Crohn’s disease, ulcerative colitis patients and healthy controls n(%)

Repeat No.	Size (bp)	Controls	CD	P value	OR(95%CI)	UC	P value	OR(95%CI)
		2n = 596	2n = 262			2n = 120
7	171	2 (0.3)	1 (0.4)	0.91	1.13 (0.10-12.6)	3 (2.5)	0.0092	7.61 (1.25-46.08)
8	176	37 (6.2)	30 (11.4)	0.0081	1.95 (1.17-3.23)	9 (7.5)	0.59	1.22 (0.57-2.61)
9	181	75 (12.5)	43 (16.4)	0.13	1.36 (0.90-2.04)	11 (9.1)	0.29	0.70 (0.36-1.36)
10	186	89 (15.0)	33 (12.6)	0.36	0.82 (0.53-1.26)	13 (10.8)	0.24	0.69 (0.37-1.28)
11	191	90 (15.1)	35 (13.3)	0.50	0.86 (0.56-1.32)	10 (8.3)	0.053	0.51 (0.25-1.01)
12	196	131 (22.0)	57 (21.7)	0.94	0.98 (0.69-1.40)	24 (20.0)	0.63	0.88 (0.54-1.44)
13	201	99 (16.6)	31 (11.8)	0.07	0.67 (0.43-1.03)	19 (15.8)	0.83	0.94 (0.55-1.61)
14	206	36 (6.2)	24 (9.1)	0.09	1.56 (0.91-2.68)	14 (11.6)	0.024	2.05 (1.07-3.94)
15	211	33 (5.5)	8 (3.0)	0.11	0.53 (0.24-1.18)	14 (11.6)	0.015	2.25 (1.16-4.35)
16	216	4 (0.6)	0 (0)	0.18	0 (0)	3 (2.5)	0.06	3.79 (0.83-17.18)

¹P = 0.008, OR (95%CI): 1.95 (1.17-3.23): P_c = 0.08;

²P = 0.009; OR (95%CI): 7.61 (1.25-46.08): P_c = 0.09;

³P = 0.05; OR (95%CI): 0.51 (0.25-1.01): P_c = 0.5;

⁴P = 0.02; OR(95%CI): 2.05 (1.07-3.94): P_c = 0.2;

⁵P = 0.01; OR(95%CI): 2.25 (1.16-4.35): P_c = 0.1. CD: Crohn’s disease; UC: Ulcerative colitis.