Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease

Table 3 Genotype and genetic models distribution of HIF1A and NFKB1 SNPs in inflammatory bowel disease patients and controls n (%)

SNP ID	1/2	Subgroup	Genotype			Genotype 11+12 vs 221		Genotype 11 vs 12+222
						OR (95%CI)	P value	OR (95%CI)	P value
HIF1A	A/G		AA	GA	GG
rs11549467		Controls	4 (1.30)	66 (21.43)	238 (77.27)
		IBD	2 (1.01)	46 (23.12)	151 (75.88)	1.08 (0.71-1.64)	0.71	0.77 (0.14-4.25)	0.76
		CD	2 (1.47)	32 (23.53)	102 (75.00)	1.13 (0.70-1.81)	0.60	1.13 (0.20-6.26)	0.88
		UC	0 (0.00)	14 (22.22)	49 (77.78)	0.97 (0.50-1.86)	0.93	NA	0.99
NFKB1	Del/Ins		del/del	ins/del	ins/ins
rs28362491		Controls	58 (18.83)	141 (45.78)	109 (35.39)
		IBD	37 (18.59)	93 (46.73)	69 (34.67)	1.03 (0.71-1.5)	0.86	0.98 (0.62-1.55)	0.94
		CD	25 (18.38)	63 (46.32)	48 (35.29)	1.00 (0.65-1.53)	0.98	0.97 (0.57-1.63)	0.91
		UC	12 (19.05)	30 (47.62)	21 (33.33)	1.09 (0.61-1.94)	0.75	1.01 (0.50-2.02)	0.96

¹Dominant model;

²Recessive model. IBD: Inflammatory bowel disease; CD: Crohn’s disease; UC: Ulcerative colitis; NA : Not applicable.