Efficacy of noninvasive evaluations in monitoring inflammatory bowel disease activity: A prospective study in China

Table 6 Sensitivity, specificity, positive predictive value, and negative predictive value of FC, CDAI/CAI, CRP, ESR, and CAF in predicting endoscopic active disease in three groups of inflammatory bowel disease patients

	FC ≥ 250 μg/g	CDAI > 150/CAI > 4	CRP ≥ 5 mg/L	ESR ≥ 10 mm/h	CFA ≥ 850 or ≥ 150
Colonic or ileum-colonic CD (%)
Sensitivity	97.1	60	71.4	82.8	91.4
Specificity	71.4	95.2	90.5	57.1	90.5
PPV	85	95.5	92.6	76.3	94.1
NPV	93.8	58.8	65.5	66.7	86.4
Accuracy	87.5	73.2	78.6	73.2	91.1
CD-related surgery (%)
Sensitivity	50.0	40.0	50.0	60.0	NA
Specificity	66.7	73.3	73.3	53.3	NA
PPV	50	50.0	55.6	46.2	NA
NPV	66.7	64.7	68.8	66.7	NA
Accuracy	60	60.0	64.0	56.0	NA
UC
Sensitivity	87.9	60.6	42.4	63.6	92.8
Specificity	100	100	100	83.3	91.7
PPV	100	100	100	91.3	96.8
NPV	75.0	48.0	38.7	45.5	78.6
Accuracy	91.1	71.1	57.8	68.89	91.1

CD: Crohn’s disease; UC: Ulcerative colitis; FC: Fecal calprotectin; CDAI/CAI: Clinical activity index; CFA: Clinical FC activity; PPV: Positive predictive value; NPV: Negative predictive value.