Efficacy of noninvasive evaluations in monitoring inflammatory bowel disease activity: A prospective study in China

Table 5 Sensitivity, specificity, positive predictive value, and negative predictive value of fecal calprotectin, CRP, and ESR in predicting endoscopic active disease in inflammatory bowel disease patients in clinical remission

	FC ≥ 250 μg/g	CRP ≥ 5 mg/L	ESR ≥ 10 mm/h
Colonic or ileum-colonic CD (%)
Sensitivity	93	46.2	61.5
Specificity	70	83.3	66.7
PPV	68.4	75.0	53.3
NPV	93.3	73.1	73.7
AUC	0.91	0.76	0.71
P value	< 0.001	0.011	0.042
UC
Sensitivity	84.6	23.1	46.2
Specificity	100	100	83.3
PPV	100	100	75.0
NPV	85.7	54.5	58.8
AUC	0.96	0.84	0.76
P value	< 0.001	0.004	0.028

CD: Crohn’s disease; UC: Ulcerative colitis; FC: Fecal calprotectin; PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the ROC curve.