Prevalence of- and risk factors for work disability in Dutch patients with inflammatory bowel disease

Table 5 Univariate and multivariate regression analyses of work disability in patients with ulcerative colitis n (%)

	Work disability	Employed	Unadj. OR (95%CI)	Adj. OR (95%CI)
n	214 (100)	664 (100)
Sex (female)	124 (58)	333 (50)	1.37 (1.00-1.87)	1.76 (1.23-2.53)
Age
< 40 yr	58 (27)	287 (43)	1.00	1.00
40-55 yr	94 (44)	277 (42)	1.68 (1.16-2.42)	1.52 (0.97-2.40)
> 55 yr	62 (29)	100 (15)	3.07 (2.01-4.69)	2.93 (1.68-5.14)
Age at diagnosis
A1: diagnosis ≤ 16 yr	18 (8)	64 (10)	1.00	1.00
A2: diagnosis 17-40 yr	124 (58)	474 (71)	0.93 (0.53-1.63)	1.06 (0.55-2.04)
A3: diagnosis > 40 yr	72 (34)	126 (19)	2.03 (1.12-3.69)	1.99 (0.92-4.28)
Disease duration
≤ 15 yr	129 (60)	439 (66)	1.00	-
> 15 yr	85 (40)	225 (34)	1.29 (0.94-1.77)
Education	208 (100)	656 (100)
Low	144 (69)	282 (43)	2.98 (2.14-4.16)	2.59 (1.81-3.70)
Smoking	206 (100)	621 (100)
Yes	30 (15)	71 (11)	1.32 (0.83-2.09)	-
Disease location
E1: proctitis1	14 (7)	54 (9)	1.00	-
E2: left-sided colitis1	54 (27)	215 (37)	97 (0.50-1.87)
E3: extensive colitis1	130 (66)	317 (54)	1.58 (0.85-2.95)
Pouch2	37 (17)	54 (8)	2.36 (1.50-3.71)	1.72 (0.81-3.65)
Stoma2	35 (16)	54 (8)	2.21 (1.40-3.49)	1.13 (0.54-2.38)
Surgery2	60 (28)	97 (15)	2.28 (1.58-3.29)	1.68 (0.75-3.75)
Medication	211 (100)	649 (100)
Anti-TNFα	53 (25)	120 (18)	1.48 (1.02-2.14)	1.33 (0.86-2.06)
Immunomodulators	139 (66)	350 (54)	1.65 (1.19-2.28)	1.58 (1.09-2.28)
Extra-intestinal manifestations2	78 (36)	130 (20)	2.36 (1.68-3.30)	2.13 (1.47-3.09)
PSC2	8 (4)	21 (3)	1.19 (0.52-2.73)	-
Complications2	37 (17)	89 (13)	1.35 (0.89-2.05)	-

¹These percentages are calculated for 198 patients with UC that were disabled for work and 586 patients with UC that were employed;

²Missing values were scored as non-present. UC: Ulcerative colitis; Unadj: Unadjusted; Adj: Adjusted; TNFα: Tumor necrosis factor alpha; PSC: Primary sclerosing cholangitis.