Prevalence of- and risk factors for work disability in Dutch patients with inflammatory bowel disease

Table 3 Univariate and multivariate regression analyses of work disability in patients with Crohn’s disease n (%)

	Work disability	Employed	Unadj. OR (95%CI)	Adj. OR (95%CI)
n	548 (100)	966 (100)
Sex (female)	397 (72)	556 (58)	1.94 (1.55-2.43)	2.03 (1.53-2.69)
Age, yr
< 40	215 (39)	537 (55)	1.00	1.00
40-55	220 (40)	335 (35)	1.64 (1.30-2.07)	0.94 (0.65-1.35)
> 55	113 (21)	94 (10)	3.00 (2.19-4.12)	1.63 (0.95-2.77)
Age at diagnosis, yr
A1: diagnosis ≤ 16	47 (9)	156 (16)	1.00	1.00
A2: diagnosis 17-40	413 (75)	719 (75)	1.91 (1.35-2.70)	2.02 (1.30-3.13)
A3: diagnosis > 40	88 (16)	91 (9)	3.21 (2.07-4.98)	3.69 (1.83-7.42)
Disease duration, yr
≤ 15	285 (52)	618 (64)	1.00	1.00
> 15	263 (48)	348 (36)	1.64 (1.32-2.03)	1.67 (1.15-2.43)
Education	537 (100)	950 (100)
Low	366 (68)	446 (47)	2.42 (1.94-3.02)	2.02 (1.55-2.64)
Smoking	508 (100)	904 (100)
Yes	180 (35)	203 (22)	1.90 (1.49-2.41)	1.45 (1.09-1.92)
Disease location
L1: ileal disease1	88 (19)	184 (23)	1.00	1.00
L2: colon disease1	138 (30)	263 (33)	1.10 (0.79-1.52)	1.10 (0.75-1.61)
L3: ileocolon disease1	237 (51)	359 (44)	1.38 (1.02-1.87)	1.29 (0.91-1.83)
L4: upper GI disease2	52 (9)	82 (8)	1.13 (0.79-1.63)	-
P: peri-anal disease2	170 (31)	256 (26)	1.25 (0.99-1.57)	1.03 (0.77-1.37)
Disease behavior CD
Fistulising disease2	95 (17)	156 (16)	1.09 (0.82-1.44)	-
Stricturing disease2	145 (26)	248 (26)	1.04 (0.82-1.32)	-
Penetrating disease2	72 (13)	128 (13)	0.99 (0.73-1.35)	-
Pouch2	12 (2)	17 (1.8)	1.25 (0.59-2.64)	-
Stoma2	96 (18)	108 (11)	1.69 (1.25-2.27)	1.15 (0.78-1.69)
Surgery2	288 (53)	406 (42)	1.53 (1.24-1.89)	1.48 (1.10-2.00)
Medication	537 (100)	949 (100)
Anti-TNFα	309 (58)	435 (46)	1.60 (1.29-1.98)	1.86 (1.43-2.43)
Immunomodulators	395 (74)	698 (74)	1.00 (0.79-1.27)	-
Extra-intestinal manifestations2	229 (42)	294 (30)	1.64 (1.32-2.04)	1.36 (1.05-1.77)
PSC2	7 (1.3)	14 (1.5)	0.88 (0.35-2.19)	-
Complications2	155 (28)	223 (23)	1.31 (1.04-1.67)	1.18 (0.88-1.59)

¹These percentages are calculated for 463 patients with CD that were disabled for work and 806 patients with CD that were employed;

²Missing values were scored as non-present. CD: Crohn’s disease; Unadj: Unadjusted; TNFα: Tumor necrosis factor alpha; PSC: Primary sclerosing cholangitis.