In vivo hepatic differentiation potential of human umbilical cord-derived mesenchymal stem cells: Therapeutic effect on liver fibrosis/cirrhosis

Table 1 Impact of mesenchymal stem cells on liver function indexes in each group (n = 10, mean ± SD)

Group		ALT(U/L)	AST(U/L)	ALB(g/L)	TBIL (µmol/L)	DBIL (µmol/L)
Liver fibrosis groups	Saline/CCl4 1 wk	141.00 ± 16.33	150.76 ± 15.13	29.99 ± 1.53	0.97 ± 0.15	0.70 ± 0.02
	MSCs/CCl4 1 wk	130.32 ± 15.35	142.32 ± 14.24	32.17 ± 2.25	0.93 ± 0.08	0.60 ± 0.04
	Saline/CCl4 2 wk	152.35 ± 14.56	172.22 ± 19.34	24.54 ± 1.21	1.51 ± 0.21	0.90 ± 0.07
	MSCs/CCl4 2 wk	132.88 ± 13.23a	146.23 ± 13.23a	26.60 ± 2.34	1.33 ± 0.25	0.70 ± 0.05
	Saline/CCl4 4 wk	239.24 ± 26.32	262.34 ± 28.12	28.12 ± 2.13	2.10 ± 0.23	1.10 ± 0.17
	MSCs/CCl4 4 wk	192.32 ± 21.24b	204.52 ± 23.24b	21.12 ± 1.94b	1.57 ± 0.15b	0.50 ± 0.03b
Liver cirrhosis groups	Saline/CCl4 2 wk	334.36 ± 37.48	375.24 ± 41.26	26.55 ± 1.51	2.27 ± 0.15	1.32 ± 0.12
	MSCs/CCl4 2 wk	204.31 ± 22.52c	289.13 ± 32.22c	19.62 ± 1.54	1.90 ± 0.14c	0.80 ± 0.09c
	Saline/CCl4 4 wk	353.35 ± 38.76	406.24 ± 44.31	22.69 ± 2.72	3.34 ± 0.76	2.07 ± 0.15
	MSCs/CCl4 4 wk	214.11 ± 23.24d	292.24 ± 32.32d	20.36 ± 1.53d	2.06 ± 0.14d	1.10 ± 0.13d
	Saline/CCl4 8 wk	391.22 ± 43.57	418.63 ± 45.71	19.31 ± 1.52	4.82 ± 0.52	3.74 ± 0.25
	MSCs/CCl4 8 wk	247.31 ± 27.36e	307.22 ± 34.36e	23.70 ± 7.72e	3.32 ± 0.31e	2.13 ± 0.15e

^aP < 0.05 vs Saline/CCl₄ 2 wk,

^bP < 0.05 vs Saline/CCl₄ 4 wk (in the liver fibrosis groups);

^cP < 0.05 vs Saline/CCl₄ 2 wk,

^dP < 0.01 vs Saline/CCl₄ 4 wk, and

^eP < 0.01 vs Saline/CCl₄ 8 wk (in the liver cirrhosis groups). ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALB: Albumin; TBIL: Total bilirubin; DBIL: Direct bilirubin.