Retreatment of patients with treatment failure of direct-acting antivirals: Focus on hepatitis C virus genotype 1b

Table 2 Resistance-associated substitutions or treatment-emergent substitutions of hepatitis C virus NS5B nucleos(t)ide inhibitors

Domains of HCV NS5B polymerase[45]	HCV genotypes (GTs)			Ref.
	GT1	GT1a	GT1b
Fingers domain (AA1-188, 226-287)		C14R		[40]
		D61G		[40]
			T77T/A	[41]
	S96T			[42]
	N142T		N142S	[40,42]
	L159F			[40-44]
		E237G		[40]
	S282T	S282R		[40-42]
Palm domain (AA188-226, 287-371)	M289I/L			[42,44]
		L314P		[40]
			C316R	[41]
	L320F	L320I/V		[40-42]
	V321A	V321I		[40,42,43]
		T344I		[40]
Thumb domain (AA371-530)		F415Y		[43]
			E440G, E/G	[42]
		S470G		[40]

β-hairpin, AA443-453; C-term linker, AA530-565[44]. HCV: Hepatitis C virus.