Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study

Table 2 Baseline patient characteristics

	Combination diuretic (n = 28)	Conventional diuretic (n = 28)	P value
Hemoglobin, g/dL	9.43 ± 1.30	10.3 ± 1.62	0.0481
Platelets, × 103/μL	10.1 ± 7.96	12.3 ± 6.04	0.0598
Prothrombin time, s	12.5 ± 1.5	12.3 ± 1.1	0.4672
Serum albumin, g/dL	2.38 ± 0.49	2.36 ± 0.55	0.9934
BUN, g/dL	24.7 ± 14.6	27.1 ± 24.7	0.8058
Serum creatinine, mg/dL	1.14 ± 0.52	1.03 ± 0.42	0.4031
ALT, IU/L	31.3 ± 29.6	25.5 ± 12.2	0.7306
Total bilirubin, g/dL	3.20 ± 3.78	2.86 ± 2.96	0.7121
BNP, pg/mL	164 ± 310	97.1 ± 76.6	0.8957
HANP, pg/mL	79.5 ± 80.4	60.2 ± 33.6	0.8831
Ammonia, μg/dL	82.4 ± 48.5	75.6 ± 45.1	0.6314
Plasma-aldosterone, pg/mL	163 ± 178	185 ± 267	0.5221
Plasma-renin, pg/mL	9.04 ± 10.6	8.45 ± 14.3	0.8377
Plasma AVP, pg/mL	2.42 ± 1.52	2.35 ± 1.70	0.5007
Serum sodium, mEq/L	135 ± 5.4	135 ± 4.2	0.5869
Serum potassium, mEq/L	3.83 ± 0.52	3.99 ± 0.53	0.2301
Urinary OSM, mOSM/L	426 ± 163	413 ± 172	0.7742
Urinary sodium, mEq/d	88.8 ± 63.3	93.4 ± 65.3	0.5869
Urinary potassium, mEq/d	25.3 ± 13.8	26.8 ± 13.4	0.5497
24-h CCr, mL/min	57.3 ± 27.9	62.6 ± 38.4	0.9217

Data are expressed as median, n (%) or mean ± SD. BUN: Blood urea nitrogen; AVP: Arginine vasopressin; BNP: Brain natriuretic peptide; HANP: Human atrial natriuretic peptide; OSM: Osmolality; 24-h CCr: 24-hour creatinine clearance.