Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn’s disease

Figure 2 Receiver operating characteristic curve analysis of miR-125a/b for prediction of active Crohn's disease patients and patients with Crohn's disease in remission. Receiver operating characteristic curve was operated to assess miR-125a/b expression in differentiating A-CD patients from R-CD patients and from HCs. miR-125a was able to differentiate A-CD patients from R-CD (A) patients and from HCs (B), whereas miR-125b was not (A, B). Neither miR-125a nor miR-125b could differentiate R-CD from HCs (C). A-CD: Active Crohn's disease; R-CD: Crohn's disease in remission; HCs: Healthy controls.