Meta-Analysis
Copyright ©The Author(s) 2017.
World J Gastroenterol. Nov 28, 2017; 23(44): 7906-7916
Published online Nov 28, 2017. doi: 10.3748/wjg.v23.i44.7906
Table 1 Summary of the included randomized clinical trials
Ref.Number of centers involved (country) in the RCT and in the study periodInclusion criteriaExclusion criterianSurgical approach
Types of procedure
Preoperative treatment
Lap (n)Conversion rate (%)Open (n)Lap (%)Open (%)Lap (%)Open (%)
Fleshman et al[5], 201535 (United States-Canada) Oct 2008-Sep 2013S. II-III rectal cancer ≤ 12 cm from AV1-1146224011.25222LAR (74.6) APR (24.2) H (0.4) TPC (0.8)AR (76.1) APR (21.2) TPC 6 (2.7)CRT (95) RT (3.3) CT (1.7)CRT (91.2) RT (5.5) CT (3.4)
Stevenson et al[6], 201524 (Australia-N. Zeal) Mar 2010-Nov 2014T1-3 rectal cancer ≤ 15 cm from AV1, 2, 4, 7, 10, 12, 134732388.82235LAR (89) APR (11)AR (90) APR (10)RT (50)RT (49)
Ng et al[20], 20141 (Hong Kong) Aug 2001-Aug2007Rectal cancer low margin 5-12 cm AV13, 16, 17, 23, 24, 2580407.540LAR (100)AR (100)00
van der Pas et al[3], 201330 (Europe- Canada-South Korea) Jan 2004-May 2010T1-3 rectal cancer ≤ 15 cm from AV1, 2, 9, 10, 13-22104469916.4345LAR (70) APR (29) U (1)AR (77) APR (23)RT (59) CT (32)RT (58) CT (34)
Liang et al[24], 20111 (China) May 2004-April 2008Rectal cancer16, 25, 26, 31, 34, 353431690.59174LAR (50.9) APR (49.1)AR (59.8) APR (40.2)00
Kang et al[4], 20103 (South Korea) Apr 2006-Aug 2009T1-3 rectal cancer ≤ 9 cm from AV1, 5, 10, 13, 16, 21, 23, 263401701.18170LAR (85.9) APR (14.1)AR (88.8) APR (11.2)CRT (100)CRT (100)
Liu et al[18], 20101 (China) Feb 2005-Oct 2008Rectal cancer16, 17, 23186980881LAR (69.4) H 14 (14.3) APR (12.2) O 4 (4.1)AR (67) H (12.5) APR (15.9) O 4 (4.5)00
Ng et al[21], 20091 (Hong Kong) Sep 1993-Oct 2002Rectal cancer low margin 12-15 cm AV1, 16, 23, 24, 27, 281537630.2677LAR (100)AR (100)00
Luján et al[19], 20091 (Spain) Jan 2002-Feb 2007Mid or low rectal cancer1, 13, 18, 292041017.92103LAR 77 (76.2) APR 24 (23.8)AR (78.6) APR (21.4)CRT (72.3)CRT (74.8)
Ng et al[22], 20081 (Hong Kong) Sep1994-Feb 2005Low rectal cancer13, 16, 23, 24, 3099519.848APR (100)APR (100)00
Braga et al[17], 20071 (Italy) Period n.a.Rectal cancer1, 2, 10, 13, 31168837.2385LAR (91.6) APR (8.4)AR (87) APR (13)CRT (16.9)CRT (14.1)
Guillou et al[26], 200527 (United Kingdom) Jul 1996 - Jul 2002Colorectal cancer (excl. transverse)11, 16, 17, 21, 32, 3338125333.88128AR 167 (66) APR (25) S (3) LH (2) O (3) U (1)AR (62) RC 1 (1) S 7 (5) APR (27) O 4 (3) U (2)NANA
Zhou et al[23], 20041 (China) Jun 2001 - Sep 20021.5 cm above AV to peritoneal reflection1, 13, 29171[24]82na89LAR (100)AR (100)00
Araujo et al[25], 20031 (Brazil) Sep 1997-Sep 2000Low rectal cancer not responding RCT12813015APR (100)APR (100)CRT (100)CRT (100)