Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis

Table 6 Predictive performances of prognostic models for hepatocellular carcinoma development

Categorical variable	Rotterdam	Paris I	Barcelona	Toronto	Cirrhosis	Thrombocytopenia, < 150 × 109/L	Hyperbilirubinemia,> 17 mmol/L
AUROC	0.68	0.67	0.64	0.64	0.71	0.75	0.64
(95%CI)	(0.52-0.80)	(0.52-0.81)	(0.48-0.78)	(0.47-0.78)	(0.56-0.86)	(0.58-0.90)	(0.49-0.77)
Sensitivity	75.00%	66.60%	58.30%	63.60%	66.70%	70.00%	66.70%
Specificity	60.60%	66.60%	68.90%	63.60%	75.00%	79.00%	60.80%
PPV	14.80%	15.40%	14.60%	14.00%	19.50%	21.20%	13.60%
NPV	96.40%	95.70%	94.80%	94.90%	96.10%	97.00%	84.90%
Continuous variable	APRI	APRI-r1	Mayo risk score	MELD score	CP score
AUROC	0.68	0.77	0.7	0.63	0.62
(95%CI)	(0.49-0.87)	(0.64-0.88)	(0.54-0.84)	(0.43-0.79)	(0.47-0.76)
Sensitivity	-	-	-	-	-
Specificity	-	-	-	-	-
PPV	-	-	-	-	-
NPV	-	-	-	-	-

APRI: AST to platelet ratio index at baseline; APRI-r1: APRI at 1-year; AUROC: Area under receiver operating curve; CP: Child-Pugh; MELD: Model for end-stage liver disease; NPV: Negative predictive value; PPV: Positive predictive value.