Prediction of early-stage hepatocellular carcinoma using OncoScan chromosomal copy number aberration data

doi:10.3748/wjg.v23.i44.7818

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Nov 28, 2017 (publication date) through Nov 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2017; 23(44): 7818-7829
Published online Nov 28, 2017. doi: 10.3748/wjg.v23.i44.7818

Table 2 Disease-free survival analysis of clinicopathological data and percentage genome change of 120 patients with hepatocellular carcinoma

Clinicopathological factor	Log-rank test, P value	Cox regression analysis, P value	HR (95%CI)
Age (yr), ≤ 49 (22.5%) vs > 49 (77.5%)	0.004^a	0.169	0.674 (0.384-1.183)
Sex (M/F), M (81.7%) vs F (19.3%)	0.146
Tumor size (cm), ≤ 4.5 (69.2%) vs > 4.5 (30.8%)	0.001^a	0.012^a	1.959 (1.160-3.309)
Satellite lesions (%), Yes (7.5%) vs No (92.5%)	0.088	0.013^a	2.900 (1255-6.702)
Vascular invasion (%), Yes (28.3%) vs No (71.7%)	0.240
Grading I, II, III, IV (%), III & IV (43.3%) vs I & II (56.7%)	0.004^a	0.063	1.626 (0.974-2.717)
Margin < 0.5 cm (%), ≤ 0.5 cm (47.5%) vs > 0.5 cm (52.5%)	0.210
Cirrhosis (%), Yes (54.2%) vs No (45.8%)	0.258
AFP (100 ng/mL), £100 (77.5%) vs > 100 (22.5%)	0.006^a	0.462	1.244 (0.695-2.227)
Alkaline phosphatase (120 U/L), ≤ 120 (88.3%) vs > 120 (11.7%)	0.016^a	0.042^a	1.976 (1.025-3.808)
Staging I/II, II (40.0%) vs I (60.0%)	0.104
Percentage genome changed (60%), ≥ 60% (7.5%) vs < 60% (92.5%)	0.004^a	0.031^a	2.346 (1.080-5.097)

^aP < 0.05, statistically significant. AFP: α-fetoprotein; HCC: Hepatocellular carcinoma; HR: Hazard ratio; CI: Confidence interval; M: Male; F: Female.

Citation: Yu MC, Lee CW, Lee YS, Lian JH, Tsai CL, Liu YP, Wu CH, Tsai CN. Prediction of early-stage hepatocellular carcinoma using OncoScan chromosomal copy number aberration data. World J Gastroenterol 2017; 23(44): 7818-7829
URL: https://www.wjgnet.com/1007-9327/full/v23/i44/7818.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i44.7818