Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats

Figure 7 LanthaScreen^® TR-FRET PXR competitive binding assay was performed to determine the ability of PXR to bind to the PXR ligand binding domain and replace a fluorescent PXR ligand. SR12813, a model PXR agonist, was used as a high-affinity ligand in the PXR ligand binding domain to validate the method. The data are presented as the mean ± SD from three independent experiments (n = 3) performed in triplicate measurements. Significantly different compared to the control treatment. ^aP < 0.05, ^bP < 0.01, ^eP < 0.001.