Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats

Figure 1 Plasma liver biochemical tests, hepatic histological examination, Col1a1 mRNA expression, and PCNA and ZO-1 protein expression in sham-operated and bile duct-obstructed rats. Rats were administered either saline or resveratrol (R, 10 mg/kg) daily by oral gavage for 28 d after surgery. Liver sections were stained with Masson's blue trichrome stain for collagen visualization. Sham-operated animals were physiologically normal for the measured parameters; resveratrol administration to Sham animals had no effect. The results of mRNA and protein expression are presented as a percentage of the saline-administered sham group (control). Data are presented as the mean ± SE (n = 6); ^bP < 0.01, ^eP < 0.001 vs saline-treated sham group; ^dP < 0.01, ^fP < 0.001 vs saline-treated BDO group).