Copyright
©The Author(s) 2017.
World J Gastroenterol. Nov 14, 2017; 23(42): 7551-7562
Published online Nov 14, 2017. doi: 10.3748/wjg.v23.i42.7551
Published online Nov 14, 2017. doi: 10.3748/wjg.v23.i42.7551
Figure 3 Cytotoxic effect of BEZ235 that augments the cytotoxic activity of RIT in BxPC-3 cells.
Treatment with 90Y-ITGA6B4 alone or BEZ235 alone resulted in decreased colony formation ability in cells. Moreover, pretreatment with BEZ235 before 90Y-ITGA6B4 exposure induced stronger inhibition of the colony formation ability than that by 90Y-ITGA6B4 or BEZ235 treatment alone; moreover, plating efficiencies (PE) of cells were significantly different between the BEZ235 (+) and (-) conditions (bP < 0.01). Data represent mean ± SD, n = 3.
- Citation: Aung W, Tsuji AB, Sudo H, Sugyo A, Ukai Y, Kouda K, Kurosawa Y, Furukawa T, Saga T, Higashi T. Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor. World J Gastroenterol 2017; 23(42): 7551-7562
- URL: https://www.wjgnet.com/1007-9327/full/v23/i42/7551.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i42.7551