Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor

Figure 3 Cytotoxic effect of BEZ235 that augments the cytotoxic activity of RIT in BxPC-3 cells. Treatment with ⁹⁰Y-ITGA6B4 alone or BEZ235 alone resulted in decreased colony formation ability in cells. Moreover, pretreatment with BEZ235 before ⁹⁰Y-ITGA6B4 exposure induced stronger inhibition of the colony formation ability than that by ⁹⁰Y-ITGA6B4 or BEZ235 treatment alone; moreover, plating efficiencies (PE) of cells were significantly different between the BEZ235 (+) and (-) conditions (^bP < 0.01). Data represent mean ± SD, n = 3.