Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis

Figure 2 mRNA expression of CYP3A isoforms in rat livers. Gene expression of CYP3A1 (A) and CYP3A2 (B). Results are mean ± SEM, obtained from 8 rats of each group. ^aP < 0.05, ^bP < 0.01 vs sham-operated rats; ^eP < 0.01 and ^fP < 0.001 vs rats with mild cholestasis.