Circulating miRNAs as biomarkers for severe acute pancreatitis associated with acute lung injury

Figure 2 Differential expression of 12 circulating miRNAs were validated by quantitative reverse transcription-polymerase chain reaction. A: Validation of up-regulated expressed miRNAs. Hsa-miR-22-3p, hsa-miR-1260b, hsa-miR-762, hsa-miR-23b and hsa-miR-23a in patients with SAP with ALI were significantly up-regulated compared to patients with SAP without ALI; B: Validation of down-regulated expressed miRNAs. hsa-miR-550a*, hsa-miR-324-5p, hsa-miR-484, hsa-miR-331-3p, hsa-miR-140-3p, hsa-miR-342-3p and hsa-miR-150 were down-regulated in patients with SAP with ALI in comparison with patients with SAP without ALI. ^aP < 0.05, ^bP < 0.01. ALI: Acute lung injury; miRNA: microRNA; SAP: Severe acute pancreatitis.